Record Details

Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release
 
Creator JAYANT, RD
MCSHANE, MJ
SRIVASTAVA, R
 
Subject encapsulates subcutaneous implants
glucose sensors
in-vitro
coatings
tissue
polycation
polyanion
systems
films
assay
alginate
dexamethasone
polyelectrolyte coating
 
Description Alginate microspheres loaded with dexamethasone were prepared by the droplet generator technique. Important parameters affecting drug release, including initial drug content, the type of polyelectrolyte coating, and a combination of different ratios of coated and uncoated microspheres were investigated to achieve in vitro dexamethasone delivery with approximately zero order release kinetics, releasing up to 100% of entrapped drug within 1 month, wherein dexamethasone released at a steady rate of 4.83 mu g/day after an initial burst release period. These findings imply that these polyelectrolyte-coated alginate microspheres show promise as release systems to improve biocompatibility and prolong lifetime of implantable glucose sensors.
 
Publisher TAYLOR & FRANCIS INC
 
Date 2011-08-30T18:16:06Z
2011-12-26T12:59:06Z
2011-12-27T05:50:02Z
2011-08-30T18:16:06Z
2011-12-26T12:59:06Z
2011-12-27T05:50:02Z
2009
 
Type Article
 
Identifier DRUG DELIVERY, 16(6), 331-340
1071-7544
http://dx.doi.org/10.1080/10717540903031126
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12419
http://hdl.handle.net/10054/12419
 
Language en