Record Details

Nature and prevalence of non-additive toxic effects in industrially relevant mixtures of organic chemicals

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Nature and prevalence of non-additive toxic effects in industrially relevant mixtures of organic chemicals
 
Creator PARVEZ, SHAHID
VENKATARAMAN, CHANDRA
MUKHERJI, SUPARNA
 
Subject aromatic hydrocarbons
binary mixtures
chemical industry
industrial chemicals
organic compounds
 
Description The concentration addition (CA) and the independent action (IA) models are widely used for predicting mixture toxicity based on its composition and individual component dose–response profiles. However, the prediction based on these models may be inaccurate due to interaction among mixture components. In this work, the nature and prevalence of non-additive effects were explored for binary, ternary and quaternary mixtures composed of hydrophobic organic compounds (HOCs). The toxicity of each individual component and mixture was determined using the Vibrio fischeri bioluminescence inhibition assay. For each combination of chemicals specified by the 2n factorial design, the percent deviation of the predicted toxic effect from the measured value was used to characterize mixtures as synergistic (positive deviation) and antagonistic (negative deviation). An arbitrary classification scheme was proposed based on the magnitude of deviation (d) as: additive (⩽10%, class-I) and moderately (10 < d ⩽ 30%, class-II), highly (30 < d ⩽ 50%, class-III) and very highly (>50%, class-IV) antagonistic/synergistic. Naphthalene, n-butanol, o-xylene, catechol and p-cresol led to synergism in mixtures while 1, 2, 4-trimethylbenzene and 1, 3-dimethylnaphthalene contributed to antagonism. Most of the mixtures depicted additive or antagonistic effect. Synergism was prominent in some of the mixtures, such as, pulp and paper, textile dyes, and a mixture composed of polynuclear aromatic hydrocarbons. The organic chemical industry mixture depicted the highest abundance of antagonism and least synergism. Mixture toxicity was found to depend on partition coefficient, molecular connectivity index and relative concentration of the components.
 
Publisher Elsevier
 
Date 2009-09-12T08:38:59Z
2011-11-25T15:22:07Z
2011-12-26T13:04:42Z
2011-12-27T05:50:42Z
2009-09-12T08:38:59Z
2011-11-25T15:22:07Z
2011-12-26T13:04:42Z
2011-12-27T05:50:42Z
2009
 
Type Article
 
Identifier Chemosphere 75(11), 1429-1439
0045-6535
http://dx.doi.org/10.1016/j.chemosphere.2009.03.005
http://hdl.handle.net/10054/1631
http://dspace.library.iitb.ac.in/xmlui/handle/10054/1631
 
Language en