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Effect of achiral and mixed chiral ligands on the asymmetric synthesis of γ-nitrophosphonates via Michael addition

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Field Value
 
Title Effect of achiral and mixed chiral ligands on the asymmetric synthesis of γ-nitrophosphonates via Michael addition
 
Creator RAI, VISHAL
NAMBOOTHIRI, IRISHI NN
 
Subject enantioselectivity
stereoselectivity
catalysts
 
Description Change in the diastereo- and/or enantioselectivity were observed when the Li–cinchonine catalyzed conjugate addition of phosphonates to nitroalkenes was carried out in the presence of achiral/chiral additives. Although the conjugate addition in the absence of such additives proceeded in better yields and selectivities as reported previously, the dramatic change in selectivity in the presence of additives provides an opportunity to synthesize different stereoisomers of the product, γ-nitrophosphonate, using primarily the same chiral source.
 
Publisher Elsevier
 
Date 2009-02-16T12:00:20Z
2011-11-25T17:00:55Z
2011-12-26T13:05:59Z
2011-12-27T05:51:52Z
2009-02-16T12:00:20Z
2011-11-25T17:00:55Z
2011-12-26T13:05:59Z
2011-12-27T05:51:52Z
2008
 
Type Article
 
Identifier Tetrahedron: Asymmetry 19(7), 1-8
0957-4166
http://dx.doi.org/10.1016/j.tetasy.2008.03.006
http://hdl.handle.net/10054/661
http://dspace.library.iitb.ac.in/xmlui/handle/10054/661
 
Language en