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Comparative evaluation of heating ability and biocompatibility of different ferrite-based magnetic fluids for hyperthermia application

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Title Comparative evaluation of heating ability and biocompatibility of different ferrite-based magnetic fluids for hyperthermia application
 
Creator PRADHAN, P
GIRI, J
SAMANTA, G
SARMA, HD
MISHRA, KP
BELLARE, J
BANERJEE, R
BAHADUR, D
 
Subject iron-oxide nanoparticles
ac-losses
particles
cancer
resonance
tests
cells
mice
magnetic nanoparticle
magnetic fluid
biocompatibility
specific absorption rate
hyperthermia
 
Description In this study, lauric acid-coated, superparamagnetic, nanoparticle-based magnetic fluids of different ferrites (Fe3O4, MnFe2O4, and CoFe2O4) were prepared and compared in terms of heating ability and biocompatibility to evaluate the feasibility of use in hyperthermia treatment of cancer. All the magnetic fluids prepared had particles of average sizes 9-11 nm. Heating ability of these magnetic fluids was evaluated by calorimetric measurement of specific absorption rate (SAR) at 300 kHz frequency and 15 kA/m field. Fe3O4 and MnFe2O4 showed higher SAR (120 and 97 W/g of ferrite, respectively) than CoFe2O4 (37 W/g of ferrite). In vitro study on BHK 21 cell lines showed dose-dependent cell viability for all the magnetic fluids. Threshold-biocompatible ferrite concentration for all the magnetic fluids was 0.1 mg/mL. Above 0.2 mg/mL, CoFe2O4 was more toxic than the other magnetic fluids. On intravenous injection of different doses (50, 200, and 400 mg/kg body weight) of magnetic fluids in mice, no significant changes in hematological and biochemical parameters were observed for Fe3O4 and MnFe2O4. With CoFe2O4, an increase in SGPT levels at a dose rate of 400 mg/kg body weight was observed, indicating its mild hepatotoxic effect. However, histology of different vital organs showed no pathological changes for all the three magnetic fluids. Further, long term in vivo evaluation of biocompatibility of the lauric acid-coated ferrites is warranted. This study shows that lauric acid-coated, superparamagnetic Fe3O4 and MnFe2O4 may be used for hyperthermia treatment and are to be preferred over CoFe2O4. (c) 2006 .
 
Publisher WILEY-LISS
 
Date 2011-09-01T13:05:40Z
2011-12-26T12:59:39Z
2011-12-27T05:52:16Z
2011-09-01T13:05:40Z
2011-12-26T12:59:39Z
2011-12-27T05:52:16Z
2007
 
Type Article
 
Identifier JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 81B(1), 12-22
1552-4973
http://dx.doi.org/10.1002/jbm.b.30630
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12784
http://hdl.handle.net/10054/12784
 
Language en