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Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery

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Title Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery
 
Creator JAIN, D
BANERJEE, R
 
Subject in-vitro release
physicochemical characterization
gelatin nanoparticles
albumin nanoparticles
factorial design
carrier
biodistribution
optimization
penetration
ofloxacin
nanoparticles
protein
chitosan
solid lipid nanoparticles
ciprofloxacin hydrochloride
 
Description The aim of the present study was to develop single dose delivery systems based on nanotechnology for prolonged antibiotic release in a controlled manner. Five different drug-carrier ratios of ciprofloxacin hydrochloride-loaded nanoparticles of albumin, gelatin, chitosan (CS), and lipid [solid lipid nanoparticles (SLNs)] were prepared and characterized. Average particle size was found to be in the range of 73 +/- 2 to 98 +/- 44 nm for SLNs, 140 +/- 7 to 175 +/- 24 nm for albumin nanoparticles, 143 +/- 18 to 184 +/- 27 nm for gelatin nanoparticles, and 247 +/- 48 to 322 +/- 52 nm for CS nanoparticles. A drug-to-carrier ratio of 0.5:1 was preferred for CS nanoparticles having zeta potential of >20 mV and drug encapsulation of 35.01% +/- 2.66%. Similarly, 0.6:1 ratio was preferred for albumin nanoparticles with zeta potential >16 mV and drug encapsulation 48.20% +/- 3.01%. Zeta potentials of gelatin nanoparticles loaded with ciprofloxacin suggested that they were unstable and prone to flocculation. SLN with 0.25:1 drug carrier ratio showed 38.71% +/- 2.38% drug entrapment and -28 +/- 1 mV surface charge. All the nanoparticles showed sustained drug release avoiding "burst effect" of the free drugs for up to 120 h for albumin nanoparticles, 96 h for CS and gelatin nanoparticles, and 80 h for SLNs. The drug release profiles followed Higuchi model. Results suggest that CS nanoparticles and SLNs can act as promising carriers for sustained ciprofloxacin release in infective conditions. (C) 2007 .
 
Publisher WILEY-LISS
 
Date 2011-09-01T13:08:29Z
2011-12-26T12:59:39Z
2011-12-27T05:52:16Z
2011-09-01T13:08:29Z
2011-12-26T12:59:39Z
2011-12-27T05:52:16Z
2008
 
Type Article
 
Identifier JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 86B(1), 105-112
1552-4973
http://dx.doi.org/10.1002/jbm.b.30994
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12785
http://hdl.handle.net/10054/12785
 
Language en