Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery
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Title |
Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery
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Creator |
JAIN, D
BANERJEE, R |
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Subject |
in-vitro release
physicochemical characterization gelatin nanoparticles albumin nanoparticles factorial design carrier biodistribution optimization penetration ofloxacin nanoparticles protein chitosan solid lipid nanoparticles ciprofloxacin hydrochloride |
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Description |
The aim of the present study was to develop single dose delivery systems based on nanotechnology for prolonged antibiotic release in a controlled manner. Five different drug-carrier ratios of ciprofloxacin hydrochloride-loaded nanoparticles of albumin, gelatin, chitosan (CS), and lipid [solid lipid nanoparticles (SLNs)] were prepared and characterized. Average particle size was found to be in the range of 73 +/- 2 to 98 +/- 44 nm for SLNs, 140 +/- 7 to 175 +/- 24 nm for albumin nanoparticles, 143 +/- 18 to 184 +/- 27 nm for gelatin nanoparticles, and 247 +/- 48 to 322 +/- 52 nm for CS nanoparticles. A drug-to-carrier ratio of 0.5:1 was preferred for CS nanoparticles having zeta potential of >20 mV and drug encapsulation of 35.01% +/- 2.66%. Similarly, 0.6:1 ratio was preferred for albumin nanoparticles with zeta potential >16 mV and drug encapsulation 48.20% +/- 3.01%. Zeta potentials of gelatin nanoparticles loaded with ciprofloxacin suggested that they were unstable and prone to flocculation. SLN with 0.25:1 drug carrier ratio showed 38.71% +/- 2.38% drug entrapment and -28 +/- 1 mV surface charge. All the nanoparticles showed sustained drug release avoiding "burst effect" of the free drugs for up to 120 h for albumin nanoparticles, 96 h for CS and gelatin nanoparticles, and 80 h for SLNs. The drug release profiles followed Higuchi model. Results suggest that CS nanoparticles and SLNs can act as promising carriers for sustained ciprofloxacin release in infective conditions. (C) 2007 .
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Publisher |
WILEY-LISS
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Date |
2011-09-01T13:08:29Z
2011-12-26T12:59:39Z 2011-12-27T05:52:16Z 2011-09-01T13:08:29Z 2011-12-26T12:59:39Z 2011-12-27T05:52:16Z 2008 |
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Type |
Article
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Identifier |
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 86B(1), 105-112
1552-4973 http://dx.doi.org/10.1002/jbm.b.30994 http://dspace.library.iitb.ac.in/xmlui/handle/10054/12785 http://hdl.handle.net/10054/12785 |
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Language |
en
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