Evaluation of antitubercular drug-loaded surfactants as inhalable drug-delivery systems for pulmonary tuberculosis
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Title |
Evaluation of antitubercular drug-loaded surfactants as inhalable drug-delivery systems for pulmonary tuberculosis
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Creator |
CHIMOTE, G
BANERJEE, R |
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Subject |
alveolar macrophages
plga microspheres rifampicin lung formulations combination monolayers therapy infants aerosol pulmonary tuberculosis antitubercular drugs liposomes twin impinger |
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Description |
Pulmonary tuberculosis is associated with a year-long chemotherapy, poor alveolar drug levels, drug-related systemic toxicity, and patient noncompliance. In this study, exogenous pulmonary surfactant is proposed as a drug carrier for antitubercular drugs. Dipalmitoylphosphatidylcholine (DPPC), the major lung-surfactant lipid, has been combined with antitubercular drugs isoniazid (INH), rifampicin (RFM), and ethambutol (ETH) in 1:1 ratio by weight, in which drugs had a ratio of 1:23 by weight. At 37 degrees C, the formulation had better surfactant function with quicker reduction of surface tension on adsorption (32.71 +/- 0.65 mN/m) than DPPC liposomes (44.67 +/- 0.57 mN/m) and maintained 100% airway patency in a capillary surfactometer. Drug-loacted surfactant liposomes were about 2 mu m and had entrapment efficiency of 30.04%+/- 2.05%, 18.85%+/- 2.92%, and 61.47%+/- 3.32% for INH, RFM, and ETH, respectively. Sustained release of the drugs from surfactants was observed over 24 h. In vitro alveolar deposition efficiency using the twin impinger showed 12.06%+/- 1.87% of INH, 43.30%+/- 0.87% of RFM, and 22.07%+/- 2.02%, of ETH deposited in the alveolar chamber upon nebulization for a minute using a jet nebulizer. The formulation was biocompatible and stable with physicochemical properties being retained even after storage for a month at 4 degrees C. Antitubercular drug-loaded surfactants developed Could serve dual purposes of alveolar stabilization due to surfactant action and better reach of these drugs to the alveoli due to antiatelectatic effect of the surfactant. (C) 2008 . J Biomed Mater Res 89A: 281-292, 2009
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Publisher |
WILEY-LISS
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Date |
2011-09-01T13:19:44Z
2011-12-26T12:59:40Z 2011-12-27T05:52:16Z 2011-09-01T13:19:44Z 2011-12-26T12:59:40Z 2011-12-27T05:52:16Z 2009 |
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Type |
Article
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Identifier |
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 89A(2), 281-292
1549-3296 http://dx.doi.org/10.1002/jbm.a.31959 http://dspace.library.iitb.ac.in/xmlui/handle/10054/12788 http://hdl.handle.net/10054/12788 |
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Language |
en
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