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In Vitro Evaluation of Inhalable Isoniazid-Loaded Surfactant Liposomes as an Adjunct Therapy in Pulmonary Tuberculosis

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Title In Vitro Evaluation of Inhalable Isoniazid-Loaded Surfactant Liposomes as an Adjunct Therapy in Pulmonary Tuberculosis
 
Creator CHIMOTE, G
BANERJEE, R
 
Subject respiratory-distress syndrome
drug-delivery system
rifampicin
lung
infection
infants
aerosol
isoniazid
dppc
pulmonary surfactant
pulmonary tuberculosis
 
Description In this study, exogenous pulmonary surfactant was evaluated as an inhalable drug carrier for antitubercular drug isoniazid (INH). Isoniazid-entrapped liposomes of dipalmitoyl-phosphatidylcholine (DPPC) (the most abundant lipid of lung surfactant and exogenous surfactant) were developed and evaluated for size, drug entrapment, release, in vitro alveolar deposition, biocompatibility, antimycobacterial activity, and pulmonary surfactant action. Isoniazid-entrapped DPPC liposomes were about 750 nm in diameter and had entrapment efficiency of 36.7% +/- 1.8%. Sustained release of INH from DPPC liposomes was observed over 24 h. In vitro alveolar deposition efficiency using the twin impinger exhibited similar to 25-27% INH deposition in the alveolar chamber upon one minute nebulization using a jet nebulizer. At 37 degrees C, the formulation had better pulmonary surfactant function with quicker reduction of surface tension on adsorption (36.7 +/- 0.4 mN/m) than DPPC liposomes (44.7 +/- 0.6 mN/m) and 87% airway patency was exhibited by the formulation in a capillary surfactometer. The formulation was biocompatible and had antimycobacterial activity. The isoniazid-entrapped DPPC liposomes could fulfill the dual purpose of pulmonary drug delivery and alveolar stabilization due to antiatelectatic effect of the surfactant action which can improve the reach of antitubercular drug INH to the alveoli. (C) 2010 . J Biomed Mater Res Part B: Appl Biomater 946: 1-10, 2010.
 
Publisher WILEY-LISS
 
Date 2011-09-01T13:28:10Z
2011-12-26T12:59:40Z
2011-12-27T05:52:17Z
2011-09-01T13:28:10Z
2011-12-26T12:59:40Z
2011-12-27T05:52:17Z
2010
 
Type Article
 
Identifier JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 94B(1), 1-10
1552-4973
http://dx.doi.org/10.1002/jbm.b.31608
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12791
http://hdl.handle.net/10054/12791
 
Language en