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T-C-tuned Biocompatible suspension of La0.73Sr0.27MnO3 for magnetic hyperthermia

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Title T-C-tuned Biocompatible suspension of La0.73Sr0.27MnO3 for magnetic hyperthermia
 
Creator PRASAD, NK
RATHINASAMY, K
PANDA, D
BAHADUR, D
 
Subject cells in-vitro
intracellular hyperthermia
cancer-treatment
nanoparticles
strontium
microtubules
powders
site
biocompatibility/soft tissue
in vitro
nanomaterials/nanophase
tissue culture
microtubulles
 
Description La1-xSrxMnO3, a ferromagnet with high magnetization and Curie temperature T-C below 70 degrees C, enables its use for magnetic hyperthermia treatment of cancer with a possibility of in vivo temperature control. We found that La0.73Sr0.27MnO3 particles of size range 20-100 nm showed saturation magnetization around 38 emu/g at 20 kOe and a T-C value of 45 degrees C. Aqueous suspension of these nanoparticles was prepared using a polymer, acrypol 934, and the biocompatibility of the suspension was examined using HeLa cells. A good heating ability of the magnetic suspension was obtained in the presence of AC magnetic field, and it was found to increase with the amplitude of field. The suspension having concentration of 0.66 mg/mL (e.g., 0.66 mg of nanoparticles with acropyl per milliliter of culture media) was observed to be biocompatible even after 96 h of treatment, as estimated by sulforhodamine B and trypan blue dye exclusion assays. Further, the treatment with the aforementioned concentration did not alter the microtubule cytoskeleton or the nucleus of the cells. However, the hare particles (concentration of 0.66 mg of nanoparticles per milliliter of culture media, but without acropyl) decreased the viability of cell significantly. Our in vitro studies suggest that the suspension (concentration of 0.66 mg/mL) may further be analyzed for in vivo studies. (c) 2007 .
 
Publisher WILEY-LISS
 
Date 2011-09-01T13:46:26Z
2011-12-26T12:59:40Z
2011-12-27T05:52:18Z
2011-09-01T13:46:26Z
2011-12-26T12:59:40Z
2011-12-27T05:52:18Z
2008
 
Type Article
 
Identifier JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 85B(2), 409-416
1552-4973
http://dx.doi.org/10.1002/jbm.b.30959
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12794
http://hdl.handle.net/10054/12794
 
Language en