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Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover

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Title Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover
 
Creator SUBRAHMANYAM, G
RUDD, CE
SCHNEIDER, H
 
Subject signal-transduction
phosphoinositide kinases
protein-kinase
cross-linking
4-kinase
3-kinase
lymphocytes
phosphorylation
requirement
expression
cd7
phosphatidylinositol 3-kinase phosphatidylinositol 4-kinase
 
Description CD7 is a 40-kDa glycoprotein that is expressed on prothymocytes and persists during T cell differentiation. CD7 has been demonstrated to generate, like other costimulatory molecules, intracellular signals that modulate T cell function. However, although it binds to phosphatidylinositol 3-kinase (PI 3-kinase), the signaling events mediated by CD7 are not completely understood. In this context, phosphatidylinositol 4-kinase (PI 4-kinase) is a key enzyme involved in a variety of events, from the modeling of the actin cytoskeleton to the activation of protein kinase C. In this study, we show for the first time that PI 4-kinase of 55 kDa can associate with CD7. The enzyme activity was insensitive to wortmannin, but was inhibited by adenosine, a characteristic for type II PI 4-kinase. Together, our findings demonstrate that type II PI 4-kinases are integral components of the CD7 signaling pathway and may play a role of CD7 in co-stimulation and thymic differentiation.
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2011-09-01T14:55:16Z
2011-12-26T12:59:41Z
2011-12-27T05:52:22Z
2011-09-01T14:55:16Z
2011-12-26T12:59:41Z
2011-12-27T05:52:22Z
2003
 
Type Article
 
Identifier EUROPEAN JOURNAL OF IMMUNOLOGY, 33(1), 46-52
0014-2980
http://dx.doi.org/10.1002/immu.200390006
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12804
http://hdl.handle.net/10054/12804
 
Language en