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Cross-enyne and ring-closing metathesis cascade: A building-block approach suitable for diversity-oriented synthesis of densely functionalized macroheterocycles with amino acid scaffolds

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Title Cross-enyne and ring-closing metathesis cascade: A building-block approach suitable for diversity-oriented synthesis of densely functionalized macroheterocycles with amino acid scaffolds
 
Creator KOTHA, S
SINGH, K
 
Subject macro-heterocycles
olefin metathesis
part i
derivatives
products
strategy
diene
amino acids
tandem reactions
metathesis
heterocycles
macrocycles
ring-closing metathesis
 
Description Suitably functionalized glycine derivatives undergo a cross-enyne and ring-closing metathesis cascade to generate macroheterocyclic ring systems in good yield. These macrocycles, prepared on the basis of a fragment coupling strategy, consist of 13-16-membered rings. To this end, 1,5-hexadiene was found to be a promising cross-coupling partner to generate macrocycles by this tandem metathesis sequence. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
 
Publisher WILEY-V C H VERLAG GMBH
 
Date 2011-09-01T15:48:40Z
2011-12-26T12:59:42Z
2011-12-27T05:52:25Z
2011-09-01T15:48:40Z
2011-12-26T12:59:42Z
2011-12-27T05:52:25Z
2007
 
Type Article
 
Identifier EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (35), 5909-5916
1434-193X
http://dx.doi.org/10.1002/ejoc.200700744
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12813
http://hdl.handle.net/10054/12813
 
Language en