Evaluation studies of technetium-99m-porphyrin (T3,4BCPP) for tumor imaging
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Title |
Evaluation studies of technetium-99m-porphyrin (T3,4BCPP) for tumor imaging
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Creator |
SUBBARAYAN, M
SHETTY, SJ SRIVASTAVA, TS NORONHA, OPD SAMUEL, AM |
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Subject |
photodynamic therapy
photosensitizers porphyrin tissue model (99m)tc-labeled porphyrin tumors photosensitizer scintiimaging |
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Description |
A water-soluble porphyrin, 5,10,15,20-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin (T3,4BCPP), was successfully labeled with (99m)Tc and biodistribution studies were performed in Wistar rats. Scintiimaging and in vivo distribution studies were also carried out in C(6)-gliomas and mammary tumor-bearing animals using a gamma camera. Tumor-to-muscle (T/M) ratios were calculated and compared with those obtained with the known tumor-seeking radiopharmaceuticals (99m)Tc(V)-DMSA (DMSA = dimercaptosuccinic acid), (99m)Tc-citrate and (201)TICl. In the case of C(6)-gliomas, the ratios were 4.2, 2.2, 4.00 and 3.0; while in the case of C(3)H/J mammary tumor, the ratios were 9.4, 8.8, 8.1 and 8.5 for T3,4BCPP, (99m)Tc(V)-DMSA, (99m)Tc-citrate and (201)TICl, respectively. Similar studies were carried out in N-methyl-N-nitrosourea (NMU)-induced mammary tumor animals and the T/M ratios obtained were 5.9, 2.0, 5.3 and 3.3 for T3,4BCPP, (99m)Tc(V)-DMSA, (99m)Tc-citrate and (201)TICl, respectively. The radiolabeled photosensitizer could perhaps be used to detect cancer non-invasively and could even prove useful in monitoring the progression/regression of tumors before, during, and after chemotherapy, radiation therapy or photodynamic therapy (PDT). Copyright (C) 2001 John Wiley Sons, Ltd.
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Publisher |
WORLD SCI PUBL CO INC
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Date |
2011-09-01T23:39:17Z
2011-12-26T12:59:50Z 2011-12-27T05:52:50Z 2011-09-01T23:39:17Z 2011-12-26T12:59:50Z 2011-12-27T05:52:50Z 2001 |
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Type |
Article
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Identifier |
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 5(12), 824-828
1088-4246 http://dx.doi.org/10.1002/jpp.546 http://dspace.library.iitb.ac.in/xmlui/handle/10054/12896 http://hdl.handle.net/10054/12896 |
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Language |
en
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