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Adaptive development of antibody repertoire under structural matching and system constraints

DSpace at IIT Bombay

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Field Value
 
Title Adaptive development of antibody repertoire under structural matching and system constraints
 
Creator JOSHI, RR
 
Subject network
immune classifier
affinity maturation
clonal selection
metadynamic-simulation
 
Description A comprehensive model of the immune classifier system is presented where the affinity between the epitope- paratope pairs is defined in terms of structural matching and compatibility with respect to important physicochemical and geometrical parameters. Effects of medium interactions (energy constraints) on adaptive maturation of affinity and clonal selection are also simulated in terms of certain cost functions. Results of implementation on some real data are presented focussing on the nonlinear effects of the probability and strength of binding interactions and the metadynamics of variation in system parameters. Importance and scope of the approach in understanding the complexity of the associated nonlinear stochastic (bio)system is highlighted.
 
Publisher WORLD SCIENTIFIC PUBL CO PTE LTD
 
Date 2011-09-01T23:57:32Z
2011-12-26T12:59:51Z
2011-12-27T05:52:51Z
2011-09-01T23:57:32Z
2011-12-26T12:59:51Z
2011-12-27T05:52:51Z
1999
 
Type Article
 
Identifier JOURNAL OF BIOLOGICAL SYSTEMS, 7(1), 53-65
0218-3390
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12901
http://hdl.handle.net/10054/12901
 
Language en