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Yagyopathy versus oral and IV drug administration: Evaluation for pulmonary tuberculosis using compartment modeling

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Title Yagyopathy versus oral and IV drug administration: Evaluation for pulmonary tuberculosis using compartment modeling
 
Creator JOSHI, RR
RAGHUVANSHI, M
PANDYA, P
 
Subject inhalation
bioavailability
deposition
absorption
yagya (homa)
pulmonary drug administration
mathematical modeling for pharmacokinetic simulation
pulmonary tuberculosis
 
Description With pulmonary drug administration gaining more and more importance, there is an obvious need for improvement in the existing methods and search for the newer ones. We have carried out the first ever study on the potentials of yagyopathy in this regard. While introducing this new mode of pulmonary drug administration, we also highlight some preliminary clinical and empirical results on drug inhalation characterization of yagyopathy that indicate its effectiveness in the treatment of pulmonary tuberculosis and thus motivate the present study. We construct mathematical models to evaluate the efficacy of this method of herbal cure vis-a-vis the common modes of oral and intravenous medication. The models are analyzed mathematically for the availability of the drug and other important pharmacokinetic features for the case when the site of infection and hence of desired activation is located in the lungs. Computer simulation experiments and validation are also carried out using available data from relevant empirical studies. The results further support significant potential of yagyopathy especially in terms of higher lung deposits, (bio) availability and residence time. The scope of yagyopathy and related research directions are discussed.
 
Publisher WORLD SCIENTIFIC PUBL CO PTE LTD
 
Date 2011-09-02T03:19:50Z
2011-12-26T12:59:56Z
2011-12-27T05:53:08Z
2011-09-02T03:19:50Z
2011-12-26T12:59:56Z
2011-12-27T05:53:08Z
2006
 
Type Article
 
Identifier JOURNAL OF BIOLOGICAL SYSTEMS, 14(3), 463-489
0218-3390
http://dx.doi.org/10.1142/S0218339006001891
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12951
http://hdl.handle.net/10054/12951
 
Language en