A highly enantioselective synthesis of (−)- and (+)-juglomycin A through Dötz annulation and asymmetric dihydroxylation
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Title |
A highly enantioselective synthesis of (−)- and (+)-juglomycin A through Dötz annulation and asymmetric dihydroxylation
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Creator |
FERNANDES, RODNEY A
CHAVAN, VIJAY P |
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Subject |
methylation
synthesis isomers temperature |
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Description |
A highly enantioselective synthesis of (−)- and (+)-juglomycin A, a quinone antibiotic is described. The synthesis is completed in eight steps, and 19% overall yield and in a high enantioselectivity of 99.5% [for (−)-juglomycin A] and 98.5% [for (+)-juglomycin A]. The synthetic strategy features an efficient combination of the Dötz annulation reaction and asymmetric dihydroxylation as the keys steps.
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Publisher |
Elsevier
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Date |
2009-02-21T11:29:22Z
2011-11-25T17:20:58Z 2011-12-26T13:05:54Z 2011-12-27T05:53:48Z 2009-02-21T11:29:22Z 2011-11-25T17:20:58Z 2011-12-26T13:05:54Z 2011-12-27T05:53:48Z 2008 |
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Type |
Article
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Identifier |
Tetrahedron Letters 49(24), 3899-3901
0040-4039 http://dx.doi.org/10.1016/j.tetlet.2008.04.059 http://hdl.handle.net/10054/733 http://dspace.library.iitb.ac.in/xmlui/handle/10054/733 |
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Language |
en
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