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Difference in the effects of surfactants and albumin on the extent of deaggregation of purpurin 18, a model of hydrophobic photosensitizer

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Title Difference in the effects of surfactants and albumin on the extent of deaggregation of purpurin 18, a model of hydrophobic photosensitizer
 
Creator MISHRA, PADMAJA P
DATTA, ANINDYA
 
Subject hydrophobicity
absorption
fluorescence
microemulsions
 
Description Absorption, fluorescence and light scattering techniques have been used to monitor the deaggregation of purpurin 18, a model of hydrophobic photosensitizers for photodynamic therapy, in aqueous micelles, microemulsions and human serum albumin. The aggregates present in the neat aqueous solvents are found to undergo deaggregation in these media to different extents. Aqueous micelles and microemulsions are found to induce a complete deaggregation whereas the process is only partial in albumins. This could be an indication of the fact that such hydrophobic photosensitizers are likely to be aggregated in the blood stream, but are probably in monomeric form, upon cellular uptake. The formation of surfactant-induced aggregates at intermediate concentrations of the positively charged CTAB is also observed and is explained in the light of electrostatic interactions between the fluorophore and the surfactant.
 
Publisher Elsevier
 
Date 2009-02-25T09:29:04Z
2011-11-25T17:48:02Z
2011-12-26T13:06:17Z
2011-12-27T05:54:05Z
2009-02-25T09:29:04Z
2011-11-25T17:48:02Z
2011-12-26T13:06:17Z
2011-12-27T05:54:05Z
2006
 
Type Article
 
Identifier Biophysical Chemistry 121(3), 224-233
0301-4622
http://dx.doi.org/10.1016/j.bpc.2006.01.009
http://hdl.handle.net/10054/772
http://dspace.library.iitb.ac.in/xmlui/handle/10054/772
 
Language en