Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity
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Title |
Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity
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Creator |
SINGH, ANIL K
DAS, JOYDIP |
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Subject |
liposome
retinol retinol palmitate fluorescence |
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Description |
Absorption and fluorescence studies of retinol (vitamin A alcohol) and retinol palmitate (vitamin A palmitate) intercalated in phosphatidylcholine (PC) liposomes show that these compounds are bound to the lipid bilayer. It is further found that retinol binds liposomes with greater affinity as compared to retinol palmitate. In addition, the delivery of liposome-incorporated retinoids to the blood has also been studied and it is found that these systems reduce blood viscosity and cause less lysis of red blood cells than retinoid compounds not complexed in liposomes.
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Publisher |
Elsevier
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Date |
2009-02-19T09:42:32Z
2011-11-25T17:32:00Z 2011-12-26T13:06:23Z 2011-12-27T05:54:11Z 2009-02-19T09:42:32Z 2011-11-25T17:32:00Z 2011-12-26T13:06:23Z 2011-12-27T05:54:11Z 1998 |
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Type |
Article
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Identifier |
Biophysical Chemistry 73(1-2), 155-162
0301-4622 http://dx.doi.org/10.1016/S0301-4622(98)00158-6 http://hdl.handle.net/10054/710 http://dspace.library.iitb.ac.in/xmlui/handle/10054/710 |
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Language |
en
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