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Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy

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Title Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy
 
Creator KOTHA, SAMBASIVARAO
BRAHMACHARY, ENUGURTHI
 
Subject phenylalanine derivatives
dialkyne building blocks
cycloaddition
 
Description A simple synthesis of dialkyne building blocks (6, 7, 8 and 9) embodying amino acid moiety is described. The dialkyne 6 participated in a [2+2+2] cycloaddition reaction with various monoalkynes in presence of Wilkinson's catalyst to give 5- and 5,6-disubstituted indan-based α-amino acid derivatives. Cobalt catalyst [e.g., CpCo(CO)2] has also been employed in the synthesis of various 2-indanyl glycine derivatives via co-trimerization reaction of the diyne building blocks 6 and 7 with several monoalkynes.
 
Publisher Elsevier
 
Date 2009-02-26T06:04:36Z
2011-11-25T17:55:03Z
2011-12-26T13:06:27Z
2011-12-27T05:54:16Z
2009-02-26T06:04:36Z
2011-11-25T17:55:03Z
2011-12-26T13:06:27Z
2011-12-27T05:54:16Z
2002
 
Type Article
 
Identifier Bioorganic & Medicinal Chemistry 10(7), 2291-2295
0968-0896
http://dx.doi.org/10.1016/S0968-0896(02)00039-1
http://hdl.handle.net/10054/786
http://dspace.library.iitb.ac.in/xmlui/handle/10054/786
 
Language en