Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy
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Title |
Synthesis of constrained phenylalanine derivatives via a [2+2+2] cycloaddition strategy
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Creator |
KOTHA, SAMBASIVARAO
BRAHMACHARY, ENUGURTHI |
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Subject |
phenylalanine derivatives
dialkyne building blocks cycloaddition |
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Description |
A simple synthesis of dialkyne building blocks (6, 7, 8 and 9) embodying amino acid moiety is described. The dialkyne 6 participated in a [2+2+2] cycloaddition reaction with various monoalkynes in presence of Wilkinson's catalyst to give 5- and 5,6-disubstituted indan-based α-amino acid derivatives. Cobalt catalyst [e.g., CpCo(CO)2] has also been employed in the synthesis of various 2-indanyl glycine derivatives via co-trimerization reaction of the diyne building blocks 6 and 7 with several monoalkynes.
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Publisher |
Elsevier
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Date |
2009-02-26T06:04:36Z
2011-11-25T17:55:03Z 2011-12-26T13:06:27Z 2011-12-27T05:54:16Z 2009-02-26T06:04:36Z 2011-11-25T17:55:03Z 2011-12-26T13:06:27Z 2011-12-27T05:54:16Z 2002 |
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Type |
Article
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Identifier |
Bioorganic & Medicinal Chemistry 10(7), 2291-2295
0968-0896 http://dx.doi.org/10.1016/S0968-0896(02)00039-1 http://hdl.handle.net/10054/786 http://dspace.library.iitb.ac.in/xmlui/handle/10054/786 |
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Language |
en
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