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First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions

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Title First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions
 
Creator KOTHA, SAMBASIVARAO
HALDER, SOMNATH
DAMODHARAN, LAKSHMINARASIMHAN
PATTABHI, VASANTHA
 
Subject macrocylic cyclophane
phase-transfer catalysis
ptc
 
Description First synthesis of a macrocylic cyclophane-based unusual α-amino acid derivative 11 by coupling of ethyl isocyanoacetate with 1,2-bis(4-bromomethylphenyl)ethane under phase-transfer catalysis (PTC) conditions. Phosphazene base such as 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) is useful to improve the yield of cyclophane derivative without high dilution conditions.
 
Publisher Elsevier
 
Date 2009-02-24T12:18:04Z
2011-11-25T17:42:01Z
2011-12-26T13:06:28Z
2011-12-27T05:54:18Z
2009-02-24T12:18:04Z
2011-11-25T17:42:01Z
2011-12-26T13:06:28Z
2011-12-27T05:54:18Z
2002
 
Type Article
 
Identifier Bioorganic & Medicinal Chemistry Letters 12(7), 1113-1115
0960-894X
http://dx.doi.org/10.1016/S0960-894X(02)00068-9
http://hdl.handle.net/10054/760
http://dspace.library.iitb.ac.in/xmlui/handle/10054/760
 
Language en