Record Details

pH Effect on the binding of chlorin derivatives with Cremophor EL, a potential drug delivery vehicle

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title pH Effect on the binding of chlorin derivatives with Cremophor EL, a potential drug delivery vehicle
 
Creator PATEL, SUNITA
DATTA, ANINDYA
 
Subject chlorine
derivatives
fluorescence
drug products
 
Description The binding of chlorin p6 with Cremophor EL (CrEL) at pH 5 and pH 7 has been monitored by fluorescence techniques. Upon binding with the drug delivery agent, the fluorescent species are found to be one and the same at both pH values. This is explained by a hindrance to protonation of chlorin p6 trianions by Cremophor EL. Surprisingly, it is the more hydrophilic species between the two possible chlorin p6 ions that is found to get bound preferentially with the hydrophobic delivery medium.
 
Publisher Elsevier
 
Date 2009-03-02T09:26:43Z
2011-11-25T18:12:06Z
2011-12-26T13:06:32Z
2011-12-27T05:54:22Z
2009-03-02T09:26:43Z
2011-11-25T18:12:06Z
2011-12-26T13:06:32Z
2011-12-27T05:54:22Z
2005
 
Type Article
 
Identifier Chemical Physics Letters 413(1-3), 31-35
0009-2614
http://dx.doi.org/10.1016/j.cplett.2005.07.062
http://hdl.handle.net/10054/822
http://dspace.library.iitb.ac.in/xmlui/handle/10054/822
 
Language en