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Synthesis and characterization of Sn(IV) complexes of lower rim 1,3-diacid derivative of calix[4]arene and their protective effects on tissue oxidative stress and essential metal concentration in lead exposed male Wistar rats

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Title Synthesis and characterization of Sn(IV) complexes of lower rim 1,3-diacid derivative of calix[4]arene and their protective effects on tissue oxidative stress and essential metal concentration in lead exposed male Wistar rats
 
Creator AMJAD ALI
FLORA, SWARAN JS
SAXENA, GEETU
KOLEHMAINEN, ERKKI
BERNARD, MAHIEU
RAO, CHEBROLU P
 
Subject tetranuclear tin complexes
hematological parameters
hepatic and renal soft tissue
reversal of lead toxicity in wistar rats
 
Description The two Sn(IV) complexes synthesized using calix[4]arene-1,3-di-acid derivative were characterized by analytical, 1H, 13C and 119Sn NMR, matrix assisted laser desorption ionization mass, and 119Sn Mossbauer techniques and found that the complexes are tetranuclear possessing structurally two different types of tin centers. These complexes were evaluated for their protective value against blood and tissue oxidative stress in lead exposed male albino rats of Wistar strain. The results suggest that the two tin complexes significantly protect changes in lead induced biochemical variables indicative of heme synthesis pathway and exhibit only moderate effect on tissue oxidative stress. The beneficial effects could be attributed mainly to the ability of Sn(IV) complexes in preventing absorption of lead to the target sites/tissues.
 
Publisher Elsevier
 
Date 2009-03-02T09:28:32Z
2011-11-25T18:16:37Z
2011-12-26T13:06:39Z
2011-12-27T05:54:39Z
2009-03-02T09:28:32Z
2011-11-25T18:16:37Z
2011-12-26T13:06:39Z
2011-12-27T05:54:39Z
2006
 
Type Article
 
Identifier Journal of Inorganic Biochemistry 100(2), 206-213
0162-0134
http://dx.doi.org/10.1016/j.jinorgbio.2005.11.008
http://hdl.handle.net/10054/831
http://dspace.library.iitb.ac.in/xmlui/handle/10054/831
 
Language en