Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross-talk
DSpace at IIT Bombay
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Title |
Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross-talk
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Creator |
MUTALIK, VIVEK K
SINGH, ADITYA P EDWARDS, JEREMY S VENKATESH, KV |
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Subject |
signal amplification
ultrasensitivity robustness mitogen activated protein kinase enzyme cascade crosstalk |
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Description |
A steady-state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen-activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensured that the modifying enzymes at various steps of the cascade were nearly saturated. Thus, there was no change in the response sensitivity with increasing upstream kinase concentration. Analysis was also extended to branching of a signaling pathway as an example of cross-talk. It was observed that the cascade structure confers a larger share of the signal transduction properties to its last kinase. This phenomenon in enzyme cascades may explain how the response of the terminal MAP kinase is unaffected by cross-talk of upstream kinases.
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Publisher |
Elsevier
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Date |
2009-03-09T07:44:13Z
2011-11-25T18:51:42Z 2011-12-26T13:06:57Z 2011-12-27T05:54:55Z 2009-03-09T07:44:13Z 2011-11-25T18:51:42Z 2011-12-26T13:06:57Z 2011-12-27T05:54:55Z 2004 |
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Type |
Article
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Identifier |
FEBS Letters 558(1-3), 79-84
0014-5793 http://dx.doi.org/10.1016/S0014-5793(04)00021-3 http://hdl.handle.net/10054/906 http://dspace.library.iitb.ac.in/xmlui/handle/10054/906 |
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Language |
en
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