Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
DSpace at IIT Bombay
View Archive InfoField | Value | |
Title |
Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
|
|
Creator |
NIGAM, S
BARICK, KC BAHADUR, D |
|
Subject |
nanoparticle
iron oxide surface functionalization drug release hyperthermia iron-oxide nanoparticles magnetite nanoparticles fluorescence spectroscopy model membranes citric-acid binding phospholipids particles liposomes transport |
|
Description |
We demonstrate a single-step facile approach for the fabrication of citric acid functionalized (citrate-stabilized) Fe(3)O(4) aqueous colloidal magnetic nanoparticles (CA-MNP) of size 8-10 nm using soft chemical route. The surface functionalization of Fe(3)O(4) nanoparticles with citric acid was evident from infrared spectroscopy, thermal and elemental analyses, and zeta-potential measurements. The drug-loading efficiency of CA-MNP was investigated using doxorubicin hydrochloride (DOX) as a model drug to evaluate their potential as a carrier system. The quenching of fluorescence intensity and decrease in surface charge of drug loaded CA-MNP strongly suggest the interaction/attachment of drug molecules with CA-MNP. More specifically, the present investigation discusses a method for entrapping positively charged drugs on to the surface of negatively charged CA-MNP through electrostatic interactionsandsuggeststhatbounddrugmoleculeswillbereleasedinappreciableamountsinthe mild acidic environments of the tumors. Furthermore, the aqueous colloidal stability, optimal magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells suggested that CA-MNP is appropriate candidate for biomedical applications. (C) 2010 Elsevier B.V. All rights reserved.
|
|
Publisher |
ELSEVIER SCIENCE BV
|
|
Date |
2011-12-29T08:30:53Z
2011-12-29T08:30:53Z 2011 |
|
Type |
Article
|
|
Identifier |
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,323(2)237-243
0304-8853 http://dx.doi.org/10.1016/j.jmmm.2010.09.009 http://hdl.handle.net/100/13798 |
|
Language |
English
|
|