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Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications

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Title Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
 
Creator NIGAM, S
BARICK, KC
BAHADUR, D
 
Subject nanoparticle
iron oxide
surface functionalization
drug release
hyperthermia
iron-oxide nanoparticles
magnetite nanoparticles
fluorescence spectroscopy
model membranes
citric-acid
binding
phospholipids
particles
liposomes
transport
 
Description We demonstrate a single-step facile approach for the fabrication of citric acid functionalized (citrate-stabilized) Fe(3)O(4) aqueous colloidal magnetic nanoparticles (CA-MNP) of size 8-10 nm using soft chemical route. The surface functionalization of Fe(3)O(4) nanoparticles with citric acid was evident from infrared spectroscopy, thermal and elemental analyses, and zeta-potential measurements. The drug-loading efficiency of CA-MNP was investigated using doxorubicin hydrochloride (DOX) as a model drug to evaluate their potential as a carrier system. The quenching of fluorescence intensity and decrease in surface charge of drug loaded CA-MNP strongly suggest the interaction/attachment of drug molecules with CA-MNP. More specifically, the present investigation discusses a method for entrapping positively charged drugs on to the surface of negatively charged CA-MNP through electrostatic interactionsandsuggeststhatbounddrugmoleculeswillbereleasedinappreciableamountsinthe mild acidic environments of the tumors. Furthermore, the aqueous colloidal stability, optimal magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells suggested that CA-MNP is appropriate candidate for biomedical applications. (C) 2010 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-12-29T08:30:53Z
2011-12-29T08:30:53Z
2011
 
Type Article
 
Identifier JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,323(2)237-243
0304-8853
http://dx.doi.org/10.1016/j.jmmm.2010.09.009
http://hdl.handle.net/100/13798
 
Language English