Multi-objective optimization of glycopeptide antibiotic production in batch and fed batch processes
DSpace at IIT Bombay
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Title |
Multi-objective optimization of glycopeptide antibiotic production in batch and fed batch processes
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Creator |
MAITI, SK
LANTZ, AE BHUSHAN, M WANGIKAR, PP |
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Subject |
SORTING GENETIC ALGORITHM
RIFAMYCIN-B FERMENTATION PARETO-OPTIMAL SOLUTIONS L-LACTIC ACID FEEDING STRATEGIES MODEL BIOREACTORS INFECTIONS Multi-objective optimization Pareto optimal Glycopeptide antibiotic Batch Fed batch |
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Description |
Fermentation optimization involves potentially conflicting multiple objectives such as product concentration and production media cost. Simultaneous optimization of these objectives would result in a multiobjective optimization problem, which is characterized by a set of multiple solutions, knows as pareto optimal solutions. These solutions gives flexibility in evaluating the trade-offs and selecting the most suitable operating policy. Here, epsilon-constraint approach was used to generate the pareto solutions for two objectives: product concentration and product per unit cost of media, for batch and fed batch operations using process model for Amycolatopsis balhimycina, a glycopeptide antibiotic producer. This resulted in a set of several pareto optimal solutions with the two objectives ranging from (0.75 g l(-1) 3.97 g $(-1)) to (0.44 g l(-1), 5.19 g $(-1)) for batch and from (1.5 g l(-1) 5.46 g $(-1)) to (1.1 g l(-1), 6.34 g $(-1)) for fed batch operations. One pareto solution each for batch and for fed batch mode was experimentally validated. (C) 2011 Elsevier Ltd. All rights reserved.
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Publisher |
ELSEVIER SCI LTD
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Date |
2012-06-26T06:18:08Z
2012-06-26T06:18:08Z 2011 |
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Type |
Article
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Identifier |
BIORESOURCE TECHNOLOGY,102(13)6951-6958
0960-8524 http://dx.doi.org/10.1016/j.biortech.2011.03.095 http://dspace.library.iitb.ac.in/jspui/handle/100/14027 |
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Language |
English
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