Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
DSpace at IIT Bombay
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Title |
Development of citrate-stabilized Fe(3)O(4) nanoparticles: Conjugation and release of doxorubicin for therapeutic applications
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Creator |
NIGAM, S
BARICK, KC BAHADUR, D |
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Subject |
IRON-OXIDE NANOPARTICLES
MAGNETITE NANOPARTICLES FLUORESCENCE SPECTROSCOPY MODEL MEMBRANES CITRIC-ACID BINDING PHOSPHOLIPIDS PARTICLES LIPOSOMES TRANSPORT Nanoparticle Iron oxide Surface functionalization Drug release Hyperthermia |
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Description |
We demonstrate a single-step facile approach for the fabrication of citric acid functionalized (citrate-stabilized) Fe(3)O(4) aqueous colloidal magnetic nanoparticles (CA-MNP) of size 8-10 nm using soft chemical route. The surface functionalization of Fe(3)O(4) nanoparticles with citric acid was evident from infrared spectroscopy, thermal and elemental analyses, and zeta-potential measurements. The drug-loading efficiency of CA-MNP was investigated using doxorubicin hydrochloride (DOX) as a model drug to evaluate their potential as a carrier system. The quenching of fluorescence intensity and decrease in surface charge of drug loaded CA-MNP strongly suggest the interaction/attachment of drug molecules with CA-MNP. More specifically, the present investigation discusses a method for entrapping positively charged drugs on to the surface of negatively charged CA-MNP through electrostatic interactionsandsuggeststhatbounddrugmoleculeswillbereleasedinappreciableamountsinthe mild acidic environments of the tumors. Furthermore, the aqueous colloidal stability, optimal magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells suggested that CA-MNP is appropriate candidate for biomedical applications. (C) 2010 Elsevier B.V. All rights reserved.
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Publisher |
ELSEVIER SCIENCE BV
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Date |
2012-06-26T07:18:03Z
2012-06-26T07:18:03Z 2011 |
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Type |
Article
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Identifier |
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,323(2)237-243
0304-8853 http://dx.doi.org/10.1016/j.jmmm.2010.09.009 http://dspace.library.iitb.ac.in/jspui/handle/100/14115 |
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Language |
English
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