Record Details

Excitability range of medium spiny neurons widens through the combined effects of inward rectifying potassium current inactivation and dopaminergic modulation

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Excitability range of medium spiny neurons widens through the combined effects of inward rectifying potassium current inactivation and dopaminergic modulation
 
Creator STEEPHEN, JE
 
Subject NUCLEUS-ACCUMBENS NEURONS
PROJECTION NEURONS
RAT
SHELL
CORE
ORGANIZATION
EXPRESSION
STRIATUM
PATTERNS
BEHAVIOR
Nucleus accumbens
Medium spiny neuron
Inward rectifying potassium current
Inactivation
Dopamine
Excitability
 
Description Due to the involvement of nucleus accumbens (NAc) medium spiny neurons (MSNs) in diverse behaviors, their excitability changes can have broad functional significance. Dopamine modulates the biophysical behavior of MSNs. In similar to 40% of MSNs, inward rectifying potassium (K(IR)) currents inactivate significantly, imparting greater excitability. Employing a 189-compartment computational model of the MSN and using spatiotemporally distributed synaptic inputs, the regulation of excitability by K(IR) inactivation and dopaminergic modulation was investigated and quantitatively characterized. It was shown that by forming different combinations, these regulating agents could fine tune MSN excitability across a wide range. With existing evidence indicating MSNs with and without K(IR) inactivation to be the likely targets for D2- and D1-receptor mediated modulations, respectively, the present findings suggest that dopaminergic channel modulation may intensify the existing excitability difference between them by suppressing the excitability of MSNs without K(IR) inactivation while further enhancing the excitability of the more excitable MSNs with K(IR) inactivation. On the other hand, the combined modulation of channels and synapses by dopamine may reverse the relative excitability of one cell type with respect to the other. (C) 2011 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2012-06-26T07:42:10Z
2012-06-26T07:42:10Z
2011
 
Type Article
 
Identifier NEUROCOMPUTING,74(18)3884-3897
0925-2312
http://dx.doi.org/10.1016/j.neucom.2011.08.003
http://dspace.library.iitb.ac.in/jspui/handle/100/14163
 
Language English