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A concise and improved synthesis of (+)-eleutherin, (+)-allo-eleutherin and a formal synthesis of (+)-nocardione B
DSpace at IIT Bombay
View Archive Info| Field | Value | |
| Title |
A concise and improved synthesis of (+)-eleutherin, (+)-allo-eleutherin and a formal synthesis of (+)-nocardione B
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| Creator |
FERNANDES, RA
CHAVAN, VP MULAY, SV |
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| Subject |
PYRANONAPHTHOQUINONE ANTIBIOTICS
ELEUTHERIN CDC25B |
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| Description |
A concise and improved stereoselective synthesis of (+)-eleutherin, (+)-allo-eleutherin and the formal synthesis of (+)-nocardione B is described. The synthesis is based on a Dotz benzannulation and an improved oxa-Pictet-Spengler cyclization as the key steps. The synthesis is achieved in six steps in overall yields of 18% for eleutherin and 20% for allo-eleutherin. (C) 2011 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTD
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| Date |
2012-06-26T08:39:10Z
2012-06-26T08:39:10Z 2011 |
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| Type |
Article
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| Identifier |
TETRAHEDRON-ASYMMETRY,22(4)487-492
0957-4166 http://dx.doi.org/10.1016/j.tetasy.2011.02.011 http://dspace.library.iitb.ac.in/jspui/handle/100/14203 |
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| Language |
English
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