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A Dotz benzannulation route to the enantioselective synthesis of (-)- and (+)-juglomycin A

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Title A Dotz benzannulation route to the enantioselective synthesis of (-)- and (+)-juglomycin A
 
Creator FERNANDES, RA
CHAVAN, VP
 
Subject ENANTIODIVERGENT TOTAL SYNTHESES
FRENOLICIN-B
ASYMMETRIC DIHYDROXYLATION
CRISAMICIN-A
EFFICIENT SYNTHESIS
KALAFUNGIN
ANTIBIOTICS
ACIDS
(-)-NANAOMYCIN-D
DEOXYFRENOLICIN
 
Description Two synthetic routes based on a Dotz benzannulation toward the enantioselective synthesis of naphthoquinone antibiotics (-)- and (+)-juglomycin A are described. The stereoinducing step is based on asymmetric dihydroxylation. The syntheses are completed in seven to eight steps from Fischer carbene 12. (C) 2011 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2012-06-26T08:40:10Z
2012-06-26T08:40:10Z
2011
 
Type Article
 
Identifier TETRAHEDRON-ASYMMETRY,22(12)1312-1319
0957-4166
http://dx.doi.org/10.1016/j.tetasy.2011.07.018
http://dspace.library.iitb.ac.in/jspui/handle/100/14205
 
Language English