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Total synthesis of topsentolide B(2)

DSpace at IIT Bombay

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Title Total synthesis of topsentolide B(2)
 
Creator FERNANDES, RA
KATTANGURU, P
 
Subject HALICHONDRIA-OKADAI KADOTA
ASYMMETRIC TOTAL-SYNTHESIS
STEREOSELECTIVE-SYNTHESIS
HALICHOLACTONE
NEOHALICHOLACTONE
ESTERS
ACID
DIHYDROXYLATION
Topsentolides
Stereoselective synthesis
Asymmetric dihydroxylation
Roush allylation
Ring closing metathesis (RCM)
 
Description A stereoselective total synthesis of topsentolide B(2), a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield. (C) 2011 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2012-06-26T08:41:41Z
2012-06-26T08:41:41Z
2011
 
Type Article
 
Identifier TETRAHEDRON LETTERS,52(15)1788-1790
0040-4039
http://dx.doi.org/10.1016/j.tetlet.2011.02.014
http://dspace.library.iitb.ac.in/jspui/handle/100/14208
 
Language English