Total synthesis of topsentolide B(2)
DSpace at IIT Bombay
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Title |
Total synthesis of topsentolide B(2)
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Creator |
FERNANDES, RA
KATTANGURU, P |
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Subject |
HALICHONDRIA-OKADAI KADOTA
ASYMMETRIC TOTAL-SYNTHESIS STEREOSELECTIVE-SYNTHESIS HALICHOLACTONE NEOHALICHOLACTONE ESTERS ACID DIHYDROXYLATION Topsentolides Stereoselective synthesis Asymmetric dihydroxylation Roush allylation Ring closing metathesis (RCM) |
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Description |
A stereoselective total synthesis of topsentolide B(2), a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield. (C) 2011 Elsevier Ltd. All rights reserved.
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Publisher |
PERGAMON-ELSEVIER SCIENCE LTD
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Date |
2012-06-26T08:41:41Z
2012-06-26T08:41:41Z 2011 |
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Type |
Article
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Identifier |
TETRAHEDRON LETTERS,52(15)1788-1790
0040-4039 http://dx.doi.org/10.1016/j.tetlet.2011.02.014 http://dspace.library.iitb.ac.in/jspui/handle/100/14208 |
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Language |
English
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