Strained dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate: a reactive precursor for the synthesis of ebselen analogs
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Title |
Strained dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate: a reactive precursor for the synthesis of ebselen analogs
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Creator |
SELVAKUMAR, K
SINGH, HB BUTCHER, RJ |
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Subject |
ACTIVE ORGANOSELENIUM COMPOUND
THYROID-HORMONE SYNTHESIS PEROXIDASE-LIKE ACTIVITY GLUTATHIONE-PEROXIDASE ANTIOXIDANT ACTIVITY ANTITHYROID DRUGS CRYSTAL-STRUCTURE SELENIUM DERIVATIVES HETEROCYCLES Selenium Ebselen Heterocycles Selenenyl halides Glutathione peroxidase |
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Description |
A facile synthesis of ebselen analogs, having Se...O(ester) secondary bonding interaction, is described. The reaction of dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate (4) with different diprotic amines such as ethanolamine, 2-chloroethylamine, and N,N'-dimethylethylenediamine afforded the ebselen analogs. Reaction of 4 with ethylenediamine and tris(2-aminoethyl)amine resulted in the formation of bis-and tris-ebselen derivatives, respectively.(C) 2011 Elsevier Ltd. All rights reserved.
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Publisher |
PERGAMON-ELSEVIER SCIENCE LTD
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Date |
2012-06-26T08:42:41Z
2012-06-26T08:42:41Z 2011 |
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Type |
Article
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Identifier |
TETRAHEDRON LETTERS,52(50)6831-6834
0040-4039 http://dx.doi.org/10.1016/j.tetlet.2011.10.067 http://dspace.library.iitb.ac.in/jspui/handle/100/14210 |
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Language |
English
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