Record Details

Synthesis of Maradolipid

DSpace at IIT Bombay

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Field Value
 
Title Synthesis of Maradolipid
 
Creator SARPE, VA
KULKARNI, SS
 
Subject ONE-POT PROTECTION
CORD-FACTOR ANALOGS
6,6'-DI-O-ACYLATED ALPHA,ALPHA-TREHALOSES
MYCOBACTERIUM-TUBERCULOSIS
DESICCATION RESISTANCE
TREHALOSE GLYCOLIPIDS
SCALE SYNTHESIS
DERIVATIVES
EFFICIENT
ALBUMIN
 
Description The first synthesis of maradolipid, a unique dissymmetrically 6,6'-di-O-acylated trehalose glycolipid isolated from C. elegans, is accomplished in five steps starting from trehalose in 45% overall yield. The short synthesis relies on dissymmetrization of trehalose core via regioselective acylation of a 2,3,4,2',3',4'-hexa-O-TMS trehalose 6,6'-diol derivative as a key step.
 
Publisher AMER CHEMICAL SOC
 
Date 2012-06-26T08:59:15Z
2012-06-26T08:59:15Z
2011
 
Type Article
 
Identifier JOURNAL OF ORGANIC CHEMISTRY,76(16)6866-6870
0022-3263
http://dx.doi.org/10.1021/jo200979n
http://dspace.library.iitb.ac.in/jspui/handle/100/14243
 
Language English