Synthesis of Maradolipid
DSpace at IIT Bombay
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Title |
Synthesis of Maradolipid
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Creator |
SARPE, VA
KULKARNI, SS |
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Subject |
ONE-POT PROTECTION
CORD-FACTOR ANALOGS 6,6'-DI-O-ACYLATED ALPHA,ALPHA-TREHALOSES MYCOBACTERIUM-TUBERCULOSIS DESICCATION RESISTANCE TREHALOSE GLYCOLIPIDS SCALE SYNTHESIS DERIVATIVES EFFICIENT ALBUMIN |
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Description |
The first synthesis of maradolipid, a unique dissymmetrically 6,6'-di-O-acylated trehalose glycolipid isolated from C. elegans, is accomplished in five steps starting from trehalose in 45% overall yield. The short synthesis relies on dissymmetrization of trehalose core via regioselective acylation of a 2,3,4,2',3',4'-hexa-O-TMS trehalose 6,6'-diol derivative as a key step.
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Publisher |
AMER CHEMICAL SOC
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Date |
2012-06-26T08:59:15Z
2012-06-26T08:59:15Z 2011 |
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Type |
Article
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Identifier |
JOURNAL OF ORGANIC CHEMISTRY,76(16)6866-6870
0022-3263 http://dx.doi.org/10.1021/jo200979n http://dspace.library.iitb.ac.in/jspui/handle/100/14243 |
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Language |
English
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