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Dendrimer-Doxorubicin conjugate for enhanced therapeutic effects for cancer

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Title Dendrimer-Doxorubicin conjugate for enhanced therapeutic effects for cancer
 
Creator CHANDRA, S
DIETRICH, S
LANG, H
BAHADUR, D
 
Subject TARGETED DRUG-DELIVERY
HOST-GUEST CHEMISTRY
MAGNETIC HYPERTHERMIA
IN-VITRO
ACID
BIOCOMPATIBILITY
CYTOTOXICITY
TOXICITY
POLYMERS
RELEASE
 
Description An oligo(ethylene glycol)-grafted amidoamine dendrimer was synthesized and characterized by FTIR, MS, (1)H and (13)C NMR. The dendritic scaffold was evaluated for its potential to load doxorubicin and its release, thereafter. The interaction between drug and the dendrimer was reviewed by zeta potential, HPLC, NMR and FTIR spectroscopy. The drug encapsulation efficiency was as high as 52%. The temperature stimulated release characteristics of the DOX loaded dendrimers were studied in PBS and SBF at 37 degrees C (physiological temperature) and 43 degrees C (hyperthermic temperature). A biphasic suspension of the dendrimer-drug conjugate and a magnetic fluid entitles release of the drug under AC magnetic field which can simultaneously be used for hyperthermia treatment of cancer. The efficacy of dendrimer-DOX conjugate was evaluated in vitro against cancer cell lines and the IC(50) was estimated.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2012-06-26T09:13:49Z
2012-06-26T09:13:49Z
2011
 
Type Article
 
Identifier JOURNAL OF MATERIALS CHEMISTRY,21(15)5729-5737
0959-9428
http://dx.doi.org/10.1039/c0jm04198j
http://dspace.library.iitb.ac.in/jspui/handle/100/14272
 
Language English