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2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester

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Title 2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester
 
Creator TRIPATHI, SK
SHARMA, S
SINGH, HB
BUTCHER, RJ
 
Subject GLUTATHIONE-PEROXIDASE ACTIVITY
ACTIVE ORGANOSELENIUM COMPOUND
ANTIOXIDANT ACTIVITY
THIOREDOXIN REDUCTASE
REMARKABLE ACTIVITY
CATALYTIC-ACTIVITY
NMR-SPECTROSCOPY
PZ-51 EBSELEN
IN-SITU
SELENOENZYME
 
Description Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good GPx-like activity in the coupled reductase assay.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2012-06-26T09:15:19Z
2012-06-26T09:15:19Z
2011
 
Type Article
 
Identifier ORGANIC & BIOMOLECULAR CHEMISTRY,9(2)581-587
1477-0520
http://dx.doi.org/10.1039/c0ob00038h
http://dspace.library.iitb.ac.in/jspui/handle/100/14275
 
Language English