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A radical cyclization approach to the formal total syntheses of platencin

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Title A radical cyclization approach to the formal total syntheses of platencin
 
Creator PALANICHAMY, K
SUBRAHMANYAM, AV
KALIAPPAN, KP
 
Subject ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS
FATTY-ACID BIOSYNTHESIS
ACTIVATED DIMETHYL-SULFOXIDE
C-ARYL GLYCOSIDES
ANTIBACTERIAL PROPERTIES
HYDROXYL GROUP
STREPTOMYCES-PLATENSIS
ENANTIOSELECTIVE ROUTE
BIOLOGICAL EVALUATION
ANTIBIOTIC PROPERTIES
 
Description Two different strategies leading to formal total syntheses of platencin are described. The first strategy involving Claisen rearrangement and radical cyclization provides a rapid access to the core structure of platencin, and also use minimum protective-group operations. The second strategy, a protecting group-free route, utilizes a 6-exo-trig radical cyclization and aldol condensation as key steps leading to the formal synthesis of platencin.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2012-06-26T09:33:50Z
2012-06-26T09:33:50Z
2011
 
Type Article
 
Identifier ORGANIC & BIOMOLECULAR CHEMISTRY,9(22)7877-7886
1477-0520
http://dx.doi.org/10.1039/c1ob06155k
http://dspace.library.iitb.ac.in/jspui/handle/100/14298
 
Language English