Forces due to curving protofilaments in microtubules
DSpace at IIT Bombay
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Title |
Forces due to curving protofilaments in microtubules
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Creator |
VICHARE, S
JAIN, I INAMDAR, MM PADINHATEERI, R |
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Subject |
STABILITY
DYNAMICS ADHESION RING INSTABILITY FILAMENT MODEL ENDS |
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Description |
Microtubules consist of 13 protofilaments arranged in the form of a cylinder. The protofilaments are composed of longitudinally attached tubulin dimers that can exist in either a less curved state [GTP-bound tubulin (T)] or a more curved state [GDP-bound tubulin (D)]. Hydrolysis of T into D leaves the straight and laterally attached protofilaments of the microtubule in a mechanically stressed state, thus leading to their unzipping. The elastic energy in the unzipping protofilaments can be harnessed by a force transducer such as the Dam1-kinetochore ring complex in order to exert pulling force on chromosomes during cell division. In the present paper we develop a simple continuum model to obtain this pulling force as a function of the mechanical properties of protofilaments and the size of the Dam1-kinetochore ring. We also extend this model to investigate the role played by the T subunits found at the plus end of the microtubule (the T cap) on the mechanical stability of microtubules.
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Publisher |
AMER PHYSICAL SOC
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Date |
2014-10-14T12:58:28Z
2014-10-14T12:58:28Z 2013 |
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Type |
Article
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Identifier |
PHYSICAL REVIEW E, 88(6)
1539-3755 1550-2376 http://dx.doi.org/10.1103/PhysRevE.88.062708 http://dspace.library.iitb.ac.in/jspui/handle/100/14463 |
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Language |
en
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