How helix-coil transition influences translocation of a single-stranded DNA and kinetics of its fluctuation inside the channel
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Title |
How helix-coil transition influences translocation of a single-stranded DNA and kinetics of its fluctuation inside the channel
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Creator |
SINGH, K
SAIN, A |
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Subject |
DRIVEN POLYMER TRANSLOCATION
POLYNUCLEOTIDE MOLECULES MEMBRANE CHANNEL ALPHA-HEMOLYSIN DISCRIMINATION PORE NANOPORE DYNAMICS HOLE |
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Description |
Many biopolymers like proteins, RNA, single-stranded DNA form secondary structures, namely helices and loops. These polymers often get transported from one compartment of the cell to another through narrow protein channels. Motivated by recent experimental results on translocation of polymers through channels and helix-coil transition inside the channel, we have constructed a two-dimensional toy model to study how secondary structures influence such processes. Through a Langevin dynamics simulation we investigated the statistics of translocation as well as how channel width, force and temperature affect the helix-coil transition inside a channel. Our results are in qualitative agreement with experimental data. Copyright (C) EPLA, 2013
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Publisher |
EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
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Date |
2014-10-15T08:08:27Z
2014-10-15T08:08:27Z 2013 |
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Type |
Article
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Identifier |
EPL, 104(1)
0295-5075 1286-4854 http://dx.doi.org/10.1209/0295-5075/104/18007 http://dspace.library.iitb.ac.in/jspui/handle/100/14644 |
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Language |
en
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