Record Details

How helix-coil transition influences translocation of a single-stranded DNA and kinetics of its fluctuation inside the channel

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title How helix-coil transition influences translocation of a single-stranded DNA and kinetics of its fluctuation inside the channel
 
Creator SINGH, K
SAIN, A
 
Subject DRIVEN POLYMER TRANSLOCATION
POLYNUCLEOTIDE MOLECULES
MEMBRANE CHANNEL
ALPHA-HEMOLYSIN
DISCRIMINATION
PORE
NANOPORE
DYNAMICS
HOLE
 
Description Many biopolymers like proteins, RNA, single-stranded DNA form secondary structures, namely helices and loops. These polymers often get transported from one compartment of the cell to another through narrow protein channels. Motivated by recent experimental results on translocation of polymers through channels and helix-coil transition inside the channel, we have constructed a two-dimensional toy model to study how secondary structures influence such processes. Through a Langevin dynamics simulation we investigated the statistics of translocation as well as how channel width, force and temperature affect the helix-coil transition inside a channel. Our results are in qualitative agreement with experimental data. Copyright (C) EPLA, 2013
 
Publisher EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
 
Date 2014-10-15T08:08:27Z
2014-10-15T08:08:27Z
2013
 
Type Article
 
Identifier EPL, 104(1)
0295-5075
1286-4854
http://dx.doi.org/10.1209/0295-5075/104/18007
http://dspace.library.iitb.ac.in/jspui/handle/100/14644
 
Language en