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A Concise Total Synthesis of (+)-Cladospolide D

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Title A Concise Total Synthesis of (+)-Cladospolide D
 
Creator SI, D
KALIAPPAN, KP
 
Subject olefin cross-metathesis
Julia-Kocienski olefination
Yamaguchi lactonization
cladospolides
total synthesis
RING-CLOSING METATHESIS
FORMAL TOTAL-SYNTHESIS
ISO-CLADOSPOLIDE-B
MEDIUM-SIZED RINGS
OLEFIN METATHESIS
ORGANIC-SYNTHESIS
EFFICIENT SYNTHESIS
NATURAL-PRODUCTS
MACROLIDE
STRATEGY
 
Description A short and convergent total synthesis of (+)-cladospolide D is delineated, which involves olefin cross metathesis and furan oxidation to access the gamma-oxo-alpha,beta-unsaturated acid and Yamaguchi lactonization to construct the 12-membered ring as key steps.
 
Publisher GEORG THIEME VERLAG KG
 
Date 2014-10-15T08:16:33Z
2014-10-15T08:16:33Z
2012
 
Type Article
 
Identifier SYNLETT, (19)2822-2826
http://dx.doi.org/10.1055/s-0032-1317520
http://dspace.library.iitb.ac.in/jspui/handle/100/14660
 
Language en