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Biomimetic sensor for certain catecholamines employing copper(II) complex and silver nanoparticle modified glassy carbon paste electrode

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Title Biomimetic sensor for certain catecholamines employing copper(II) complex and silver nanoparticle modified glassy carbon paste electrode
 
Creator SANGHAVI, BJ
MOBIN, SM
MATHUR, P
LAHIRI, GK
SRIVASTAVA, AK
 
Subject Biomimetic sensor
Catecholamines
Copper complex
Silver nanoparticles
Glassy carbon paste electrode
Adsorptive stripping voltammetry
POTENTIOMETRIC STRIPPING ANALYSIS
HYDROPHILIC INTERACTION CHROMATOGRAPHY
CHEMICALLY-MODIFIED ELECTRODES
ASCORBIC-ACID
URIC-ACID
VOLTAMMETRIC DETERMINATION
ELECTROCHEMICAL SENSOR
FOLIC-ACID
CAPILLARY-ELECTROPHORESIS
CHLORIDE COMPLEX
 
Description A dimeric Cu(II) complex [Cu(mu(2)-heP)(heP-H)]2 center dot 2ClO(4) (1) containing bidentate (hep-H=2-(2-hydroxyethyl)pyridine) ligand was synthesized and characterized by single crystal X-ray diffraction studies. Each Cu-ion in 1 is in a distorted square pyramidal geometry. Further 1 along with silver nanoparticles (SNPs) have been used as modifier in the construction of a biomimetic sensor (1-SNP-GCPE) for determining certain catecholamines viz., dopamine (DA), levodopa (L-Dopa), epinephrine (EP) and norepinephrine (NE) using cyclic voltammetry, chronocoulometry, electrochemical impedance spectroscopy and adsorptive stripping square wave voltammetry (AdSSWV). Finally, the catalytic properties of the sensor were characterized by chronoamperometry. Employing AdSSWV, the calibration curves showed linear response ranging between 10(-6) and 10(-9) M for all the four analytes with detection limits (S/N=3) of 8.52 x 10(-10) M, 2.41 x 10(-9) M, 3.96 x 10(-1) M and 3.54 x 10(-1) M for DA, L-Dopa, EP and NE respectively. The lifetime of the biomimetic sensor was 3 months at room temperature. The prepared modified electrode shows several advantages such as simple preparation method, high sensitivity, high stability, ease of preparation and regeneration of the electrode surface by simple polishing along with excellent reproducibility. The method has been applied for the selective and precise analysis of DA, L-Dopa, EP and NE in pharmaceutical formulations, urine and blood serum samples. (C) 2012 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER ADVANCED TECHNOLOGY
 
Date 2014-10-15T10:32:35Z
2014-10-15T10:32:35Z
2013
 
Type Article
 
Identifier BIOSENSORS & BIOELECTRONICS, 39(1)124-132
http://dx.doi.org/10.1016/j.bios.2012.07.008
http://dspace.library.iitb.ac.in/jspui/handle/100/14754
 
Language en