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End to end loop formation in a single polymer chain with internal friction

DSpace at IIT Bombay

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Title End to end loop formation in a single polymer chain with internal friction
 
Creator SAMANTA, N
CHAKRABARTI, R
 
Subject DIFFUSION-CONTROLLED REACTIONS
UNFOLDED POLYPEPTIDE-CHAINS
DEPENDENT SURVIVAL PROBABILITY
PROTEIN-FOLDING RATES
DYNAMICS
KINETICS
MODEL
RELAXATION
CONSTANTS
VISCOSITY
 
Description We use Rouse and Zimm models with solvent viscosity independent internal friction to study the end to end loop formation of a single polymer chain within the Wilemski-Fixmann theoretical framework. Our calculation shows internal friction makes loop formation between two ends of a polymer chain slower but has a weaker dependence on the chain length as compared to no internal friction. The average looping time shows not linear but fractional dependence on the solvent viscosity. Also the effect of the internal friction to the looping time is neither additive nor multiplicative but always additive to the reconfiguration time. Our numerical results show internal friction can reduce the looping rate by a factor of two to an order of magnitude depending on the time scale associated with it. (C) 2013 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2014-10-15T10:34:06Z
2014-10-15T10:34:06Z
2013
 
Type Article
 
Identifier CHEMICAL PHYSICS LETTERS, 58271-77
http://dx.doi.org/10.1016/j.cplett.2013.07.039
http://dspace.library.iitb.ac.in/jspui/handle/100/14757
 
Language en