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Studies on the stability and kinetics of drug release of dexamethasone phosphate intercalated layered double hydroxides nanohybrids

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Title Studies on the stability and kinetics of drug release of dexamethasone phosphate intercalated layered double hydroxides nanohybrids
 
Creator SAHOO, PK
PANDA, HS
BAHADUR, D
 
Subject Biomaterials
Nanostructures
Precipitation
Diffusion
HYDROPHILIC MATRICES
SOLID DISPERSIONS
SODIUM-PHOSPHATE
METAL HYDROXIDE
LDH NANOHYBRID
DELIVERY
POLYVINYLPYRROLIDONE
CYCLODEXTRIN
SYSTEM
 
Description We report the intercalation of dexamethasone sodium phosphate drug in Mg/Al layered double hydroxides (LDHs) through co-precipitation technique. The as-synthesized nanohybrid was characterized by XRD, FTIR and thermal analysis techniques, which reveal that the dexamethasone phosphate anions are accommodated within the brucite layers. The shifting in the stretching frequency of phosphate anion of the drug provides strong evidence that the drugs are bonded to LDHs through electrostatic force. The surface charge analysis suggested the possibility of charge manipulation in LDHs system by varying intercalated anions. In-vitro release study of as-synthesized nanohybrid particles suggests a significant reduction in release rate of dexamethasone phosphate anions from Mg/Al Dexa LDHs and is due to confinement of drugs in the interlayer. The mechanism of drugs diffusion in nanohybrid is studied by using dissolution-diffusion kinetic model, which reveals that it is probably due to dissolution and intra-particle diffusion of anions in the physiological medium. (C) 2013 Elsevier S.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE SA
 
Date 2014-10-15T10:47:55Z
2014-10-15T10:47:55Z
2013
 
Type Article
 
Identifier MATERIALS CHEMISTRY AND PHYSICS, 142(1)106-112
http://dx.doi.org/10.1016/j.matchemphys.2013.07.001
http://dspace.library.iitb.ac.in/jspui/handle/100/14784
 
Language en