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Co-production of two recombinant proteins in Escherichia coli using the promoter region of the divergently expressed curli genes

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Title Co-production of two recombinant proteins in Escherichia coli using the promoter region of the divergently expressed curli genes
 
Creator RESHAMWALA, SMS
NORONHA, SB
 
Subject Escherichia coli
Recombinant protein
Bidirectional promoter
SALMONELLA-TYPHIMURIUM
 
Description Expression of multiple proteins in a single host is desirable in biotechnological processes. The curli intergenic region in Escherichia coli contains promoter elements for the expression of the divergent csgBAC and csgDEFG operons. Using this bidirectionally active promoter region, we demonstrate high level production of two different recombinant proteins. The curli intergenic region may thus be used to produce multiple enzymes involved in biosynthetic pathways and biotransformations in a cost-effective manner. (C) 2012 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2014-10-15T11:00:12Z
2014-10-15T11:00:12Z
2013
 
Type Article
 
Identifier JOURNAL OF BIOTECHNOLOGY, 164(1)121-122
http://dx.doi.org/10.1016/j.jbiotec.2012.11.016
http://dspace.library.iitb.ac.in/jspui/handle/100/14808
 
Language en