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Proteomic Investigation of Falciparum and Vivax Malaria for Identification of Surrogate Protein Markers

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Title Proteomic Investigation of Falciparum and Vivax Malaria for Identification of Surrogate Protein Markers
 
Creator RAY, S
RENU, D
SRIVASTAVA, R
GOLLAPALLI, K
TAUR, S
JHAVERI, T
DHALI, S
CHENNAREDDY, S
POTLA, A
DIKSHIT, JB
SRIKANTH, R
GOGTAY, N
THATTE, U
PATANKAR, S
SRIVASTAVA, S
 
Subject PARTIAL LEAST-SQUARES
LARGE GENE LISTS
PLASMODIUM-FALCIPARUM
PLASMA PROTEOME
SERUM
BIOMARKERS
TOOLS
PATHOGENESIS
HAPTOGLOBIN
ACTIVATION
 
Description This study was conducted to analyze alterations in the human serum proteome as a consequence of infection by malaria parasites Plasmodium falciparum and P. vivax to obtain mechanistic insights about disease pathogenesis, host immune response, and identification of potential protein markers. Serum samples from patients diagnosed with falciparum malaria (FM) (n = 20), vivax malaria (VM) (n = 17) and healthy controls (HC) (n = 20) were investigated using multiple proteomic techniques and results were validated by employing immunoassay-based approaches. Specificity of the identified malaria related serum markers was evaluated by means of analysis of leptospirosis as a febrile control (FC). Compared to HC, 30 and 31 differentially expressed and statistically significant (p
 
Publisher PUBLIC LIBRARY SCIENCE
 
Date 2014-10-15T11:49:01Z
2014-10-15T11:49:01Z
2012
 
Type Article
 
Identifier PLOS ONE, 7(8)
http://dx.doi.org/10.1371/journal.pone.0041751
http://dspace.library.iitb.ac.in/jspui/handle/100/14828
 
Language en