Proteomic Investigation of Falciparum and Vivax Malaria for Identification of Surrogate Protein Markers
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Title |
Proteomic Investigation of Falciparum and Vivax Malaria for Identification of Surrogate Protein Markers
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Creator |
RAY, S
RENU, D SRIVASTAVA, R GOLLAPALLI, K TAUR, S JHAVERI, T DHALI, S CHENNAREDDY, S POTLA, A DIKSHIT, JB SRIKANTH, R GOGTAY, N THATTE, U PATANKAR, S SRIVASTAVA, S |
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Subject |
PARTIAL LEAST-SQUARES
LARGE GENE LISTS PLASMODIUM-FALCIPARUM PLASMA PROTEOME SERUM BIOMARKERS TOOLS PATHOGENESIS HAPTOGLOBIN ACTIVATION |
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Description |
This study was conducted to analyze alterations in the human serum proteome as a consequence of infection by malaria parasites Plasmodium falciparum and P. vivax to obtain mechanistic insights about disease pathogenesis, host immune response, and identification of potential protein markers. Serum samples from patients diagnosed with falciparum malaria (FM) (n = 20), vivax malaria (VM) (n = 17) and healthy controls (HC) (n = 20) were investigated using multiple proteomic techniques and results were validated by employing immunoassay-based approaches. Specificity of the identified malaria related serum markers was evaluated by means of analysis of leptospirosis as a febrile control (FC). Compared to HC, 30 and 31 differentially expressed and statistically significant (p
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Publisher |
PUBLIC LIBRARY SCIENCE
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Date |
2014-10-15T11:49:01Z
2014-10-15T11:49:01Z 2012 |
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Type |
Article
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Identifier |
PLOS ONE, 7(8)
http://dx.doi.org/10.1371/journal.pone.0041751 http://dspace.library.iitb.ac.in/jspui/handle/100/14828 |
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Language |
en
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