Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response
DSpace at IIT Bombay
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Title |
Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response
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Creator |
RAY, S
KAMATH, KS SRIVASTAVA, R RAGHU, D GOLLAPALLI, K JAIN, R GUPTA, SV RAY, S TAUR, S DHALI, S GOGTAY, N THATTE, U SRIKANTH, R PATANKAR, S SRIVASTAVA, S |
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Subject |
Disease pathogenesis
Immune response Plasmodium Proteomics Serum Vivax malaria PLASMODIUM-FALCIPARUM MALARIA DIFFERENCE GEL-ELECTROPHORESIS ACUTE-PHASE RESPONSE AMYLOID-P-COMPONENT C-REACTIVE PROTEIN CEREBRAL MALARIA PLASMA PROTEOME HAPTOGLOBIN CHILDREN VITAMIN |
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Description |
Vivax malaria is the most widely distributed human malaria resulting in 80-300 million clinical cases every year. It causes severe infection and mortality but is generally regarded as a benign disease and has not been investigated in detail. The present study aimed to perform human serum proteome analysis in a malaria endemic area in India to identify potential serum biomarkers for vivax malaria and understand host response. The proteomic analysis was performed on 16 age and gender matched subjects (vivax patients and control) in duplicate. Protein extraction protocols were optimized for large coverage of the serum proteome and to obtain high-resolution data. Identification of 67 differentially expressed and statistically significant (Student's t-test; p
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Publisher |
ELSEVIER SCIENCE BV
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Date |
2014-10-15T11:51:04Z
2014-10-15T11:51:04Z 2012 |
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Type |
Article
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Identifier |
JOURNAL OF PROTEOMICS, 75(10)3063-3080
1874-3919 1876-7737 http://dx.doi.org/10.1016/j.jprot.2011.10.018 http://dspace.library.iitb.ac.in/jspui/handle/100/14832 |
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Language |
en
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