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Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response

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Title Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response
 
Creator RAY, S
KAMATH, KS
SRIVASTAVA, R
RAGHU, D
GOLLAPALLI, K
JAIN, R
GUPTA, SV
RAY, S
TAUR, S
DHALI, S
GOGTAY, N
THATTE, U
SRIKANTH, R
PATANKAR, S
SRIVASTAVA, S
 
Subject Disease pathogenesis
Immune response
Plasmodium
Proteomics
Serum
Vivax malaria
PLASMODIUM-FALCIPARUM MALARIA
DIFFERENCE GEL-ELECTROPHORESIS
ACUTE-PHASE RESPONSE
AMYLOID-P-COMPONENT
C-REACTIVE PROTEIN
CEREBRAL MALARIA
PLASMA PROTEOME
HAPTOGLOBIN
CHILDREN
VITAMIN
 
Description Vivax malaria is the most widely distributed human malaria resulting in 80-300 million clinical cases every year. It causes severe infection and mortality but is generally regarded as a benign disease and has not been investigated in detail. The present study aimed to perform human serum proteome analysis in a malaria endemic area in India to identify potential serum biomarkers for vivax malaria and understand host response. The proteomic analysis was performed on 16 age and gender matched subjects (vivax patients and control) in duplicate. Protein extraction protocols were optimized for large coverage of the serum proteome and to obtain high-resolution data. Identification of 67 differentially expressed and statistically significant (Student's t-test; p
 
Publisher ELSEVIER SCIENCE BV
 
Date 2014-10-15T11:51:04Z
2014-10-15T11:51:04Z
2012
 
Type Article
 
Identifier JOURNAL OF PROTEOMICS, 75(10)3063-3080
1874-3919
1876-7737
http://dx.doi.org/10.1016/j.jprot.2011.10.018
http://dspace.library.iitb.ac.in/jspui/handle/100/14832
 
Language en