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Role of feedback and network architecture in controlling virulence gene expression in Bordetella

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Title Role of feedback and network architecture in controlling virulence gene expression in Bordetella
 
Creator PRAJAPAT, MK
SAINI, S
 
Subject 2-COMPONENT SENSOR PROTEIN
COUPLED CHEMICAL-REACTIONS
ESCHERICHIA-COLI
TRANSCRIPTIONAL ACTIVATION
DIFFERENTIAL REGULATION
BVGAS PHOSPHORELAY
CONTROL-SYSTEM
III SECRETION
PERTUSSIS
BRONCHISEPTICA
 
Description Bordetella is a Gram-negative bacterium responsible for causing whooping cough in a broad range of host organisms. For successful infection, Bordetella controls expression of four distinct classes of genes (referred to as class 1, 2, 3, and 4 genes) at distinct times in the infection cycle. This control is executed by a single two-component system, BvgAS. Interestingly, the transmembrane component of the two component system, BvgS, consists of three phospho-transfer domains leading to phosphorylation of the response regulator, BvgA. Phosphorylated BvgA then controls expression of virulence genes and also controls bvgAS transcription. In this work, we perform simulations to characterize the role of the network architecture in governing gene expression in Bordetella. Our results show that the wild-type network is locally optimal for controlling the timing of expression of the different classes of genes involved in infection. In addition, the interplay between environmental signals and positive feedback aids the bacterium identify precise conditions for and control expression of virulence genes.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-10-15T12:56:17Z
2014-10-15T12:56:17Z
2013
 
Type Article
 
Identifier MOLECULAR BIOSYSTEMS, 9(11)2635-2644
1742-206X
1742-2051
http://dx.doi.org/10.1039/c3mb70213h
http://dspace.library.iitb.ac.in/jspui/handle/100/14942
 
Language en