Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium
DSpace at IIT Bombay
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Title |
Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium
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Creator |
PRAJAPAT, MK
SAINI, S |
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Subject |
Salmonella typhimurium
Salmonella Pathogenicity Island Fur HNS T3SS AT% Transcription factors Gene expression Fimbriae Flagella ENTERICA SEROVAR TYPHIMURIUM III SECRETION SYSTEM PROTEIN H-NS PATHOGENICITY ISLAND 2 COLI NUCLEOID PROTEIN ESCHERICHIA-COLI INVASION GENES SEQUENCE-ANALYSIS COORDINATE REGULATION REGULATES EXPRESSION |
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Description |
Salmonella enterica is responsible for a large number of diseases in a wide-range of hosts. Two of the global regulators involved in controlling gene expression during the infection cycle of the bacterium are Fur and HNS. In this paper, we demonstrate computationally that Fur and HNS have disproportionately high density of binding sites in the Pathogenicity Islands on the Salmonella chromosome. Moreover, the frequency of binding sites for the two proteins is correlated throughout the genome of the organism. These results indicate a complex interplay between Fur and HNS in regulating cellular global behavior. (C) 2012 Elsevier Ltd. All rights reserved.
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Publisher |
PERGAMON-ELSEVIER SCIENCE LTD
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Date |
2014-10-15T12:56:49Z
2014-10-15T12:56:49Z 2012 |
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Type |
Article
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Identifier |
COMPUTERS IN BIOLOGY AND MEDICINE, 42(11)1133-1140
http://dx.doi.org/10.1016/j.compbiomed.2012.09.005 http://dspace.library.iitb.ac.in/jspui/handle/100/14943 |
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Language |
en
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