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Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium

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Title Interplay between Fur and HNS in controlling virulence gene expression in Salmonella typhimurium
 
Creator PRAJAPAT, MK
SAINI, S
 
Subject Salmonella typhimurium
Salmonella Pathogenicity Island
Fur
HNS
T3SS
AT%
Transcription factors
Gene expression
Fimbriae
Flagella
ENTERICA SEROVAR TYPHIMURIUM
III SECRETION SYSTEM
PROTEIN H-NS
PATHOGENICITY ISLAND 2
COLI NUCLEOID PROTEIN
ESCHERICHIA-COLI
INVASION GENES
SEQUENCE-ANALYSIS
COORDINATE REGULATION
REGULATES EXPRESSION
 
Description Salmonella enterica is responsible for a large number of diseases in a wide-range of hosts. Two of the global regulators involved in controlling gene expression during the infection cycle of the bacterium are Fur and HNS. In this paper, we demonstrate computationally that Fur and HNS have disproportionately high density of binding sites in the Pathogenicity Islands on the Salmonella chromosome. Moreover, the frequency of binding sites for the two proteins is correlated throughout the genome of the organism. These results indicate a complex interplay between Fur and HNS in regulating cellular global behavior. (C) 2012 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2014-10-15T12:56:49Z
2014-10-15T12:56:49Z
2012
 
Type Article
 
Identifier COMPUTERS IN BIOLOGY AND MEDICINE, 42(11)1133-1140
http://dx.doi.org/10.1016/j.compbiomed.2012.09.005
http://dspace.library.iitb.ac.in/jspui/handle/100/14943
 
Language en