Record Details

Pulse-Heat Aerosol Reactor (PHAR): Processing Thermolabile Biomaterials and Biomolecules into Nanoparticles with Controlled Properties

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Pulse-Heat Aerosol Reactor (PHAR): Processing Thermolabile Biomaterials and Biomolecules into Nanoparticles with Controlled Properties
 
Creator PAWAR, AA
VENKATARAMAN, C
 
Subject SOLID LIPID NANOPARTICLES
DRUG-DELIVERY
PHARMACEUTICAL SOLIDS
PARTICLE FORMATION
EVAPORATION
CRYSTALLIZATION
CRYSTALLINITY
TEMPERATURE
TECHNOLOGY
MORPHOLOGY
 
Description This work addresses the challenge of processing thermolabile biomaterials and biomolecules into nanoparticles without compromising structural integrity and activity. Control of size, structure, and crystallinity of nanoparticles is desirable for drug targeting and controlled release applications. An innovation using pulse-heat aerosol processing is demonstrated through a design of a pulse-heat aerosol reactor. Nanoparticle aerosol lipid matrices (NALM), of stearic acid, were synthesized under different processing conditions, obtained through pulse heating (fixed duration, three heat-pulse levels) and solvent selection. Operation with continuous heating resulted in ill-conditioned, multimodal size distributions. Pulse heating resulted in the synthesis of NALM with mean mobility diameter in the range of 56-183nm and narrow unimodal size distributions (geometric size distribution, GSD = 1.5-1.7). Under higher pulse levels, particles with larger mean mobility diameter were formed, which had shell-type structures, compared with smaller, solid particles under operation with low level or no heating. NALM with different degree of crystallinity were produced under different processing conditions, at which different drop temperature is expected to result. The activity of glucose oxidase enzyme was preserved, when subjected to high pulse-heat (gas temperature of 110 degrees C) aerosol processing. These results establish pulse-heat aerosol processing as a single-step, continuous method to process heat-sensitive biomaterials and biomolecules into nanoparticles with controlled properties, while avoiding thermal damage. Copyright 2013 American Association for Aerosol Research
 
Publisher TAYLOR & FRANCIS INC
 
Date 2014-10-15T13:05:02Z
2014-10-15T13:05:02Z
2013
 
Type Article
 
Identifier AEROSOL SCIENCE AND TECHNOLOGY, 47(4)383-394
http://dx.doi.org/10.1080/02786826.2012.754840
http://dspace.library.iitb.ac.in/jspui/handle/100/14959
 
Language en