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Nickel-catalyzed hydrogenolysis of unactivated carbon-cyano bonds

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Title Nickel-catalyzed hydrogenolysis of unactivated carbon-cyano bonds
 
Creator PATRA, T
AGASTI, S
MODAK, A
MAITI, D
 
Subject C-CN BOND
TRANSITION-METAL COMPLEX
REDUCTIVE CLEAVAGE
ARYL ETHERS
O BONDS
INTRAMOLECULAR ARYLCYANATION
PALLADIUM CATALYST
DIRECT CONVERSION
DIRECTING GROUPS
IRON-COMPLEX
 
Description Selective hydrogenolysis of C-CN bonds can allow chemists to take advantage of ortho-directing ability, alpha-C-H acidity and electron withdrawing ability of the cyano group for synthetic manipulations. We have discovered hydrogenolysis of aryl and aliphatic cyanides under just 1 bar of hydrogen by using a nickel catalyst. This protocol was applied in the aryl cyanide directed functionalization reaction and alpha-substitution of benzyl cyanides.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-10-15T13:09:10Z
2014-10-15T13:09:10Z
2013
 
Type Article
 
Identifier CHEMICAL COMMUNICATIONS, 49(75)8362-8364
1359-7345
1364-548X
http://dx.doi.org/10.1039/c3cc44562c
http://dspace.library.iitb.ac.in/jspui/handle/100/14967
 
Language en