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Tethered non-ionic micelles: a matrix for enhanced solubilization of lipophilic compounds

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Title Tethered non-ionic micelles: a matrix for enhanced solubilization of lipophilic compounds
 
Creator PATCHORNIK, G
NAMBOOTHIRI, INN
NAIR, DK
WACHTEL, E
PERSKY, R
 
Subject MOLECULAR-DYNAMICS SIMULATIONS
INTEGRAL MEMBRANE-PROTEINS
CLOUD POINTS
SURFACTANT ASSOCIATION
AQUEOUS-SOLUTIONS
OCTYL GLUCOSIDE
TRITON X-114
PHASE
CRYSTALLIZATION
AGGREGATION
 
Description A specific mechanism for tethering micelles composed of non-ionic detergents is presented. The mechanism does not require any precipitant, high ionic strength or temperature alterations. Rather, it relies on complexes between hydrophobic chelators embedded within the micelle and appropriate metal cations in the aqueous phase, serving as mediators. The approach was applied to: (i) four non-ionic detergents (tetraethylene glycol monooctyl ether (C8E4), n-dodecyl-beta-D-maltoside (DDM), octyl beta-D-1-thioglucopyranoside (OTG), and n-octyl-beta-D-glucopyranoside (OG)), (ii) two hydrophobic chelators (bathophenanthroline and N-(1,10-phenanthrolin-5-yl) decanamide, Phen-C10) and (iii) five transition metals (Fe2+, Ni2+, Zn2+, Cd2+, and Mn2+). The mandatory requirement for a hydrophobic chelator and transition metals, capable of binding two (or more) chelators simultaneously, was demonstrated. The potential generality of the mechanism presented derives from the observation that different combinations of [detergent : chelator : metal] are able to induce specific micellar clustering. The greater solubilization capacity of tethered-micelles in comparison with untethered micelles was demonstrated when the water insoluble aromatic molecule fluorenone (8 mM = 1.44 mg mL(-1)) and two highly lipophilic antibiotics: chloramphenicol (5 mM = 1.62 mg mL(-1)) and tetracycline (1.5 mM 0.66 mg mL(-1)) were solubilized - only when the micelles were tethered.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2014-10-15T13:24:05Z
2014-10-15T13:24:05Z
2012
 
Type Article
 
Identifier SOFT MATTER, 8(32)8456-8463
http://dx.doi.org/10.1039/c2sm25708d
http://dspace.library.iitb.ac.in/jspui/handle/100/14996
 
Language en