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Study of the preparation, properties and kinetics of anion release in drug intercalated magnetic nanohybrids

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Title Study of the preparation, properties and kinetics of anion release in drug intercalated magnetic nanohybrids
 
Creator PANDA, HS
BAHADUR, D
 
Subject Layered compounds
Magnetic materials
Intercalation reactions
Electron microscopy
LAYERED DOUBLE HYDROXIDES
IN-VITRO
SUPERPARAMAGNETIC NANOPARTICLES
SUSTAINED-RELEASE
DELIVERY
IONS
COMPOSITES
EXCHANGE
CLAYS
VIVO
 
Description We report a new magnetic nanohybrid material to make layered double hydroxides (LDHs) as a targeted drug carrier. The magnetite prepared using a modified conventional coprecipitation technique was embedded in to the fluvastatin intercalated hydrophobic anionic clay through one step process. XRD analysis shows a decrease in lattice parameter of magnetite which is due to generation of stress by the LDHs. Filtered HRTEM image indicates that the magnetic nanohybrid consists of well-defined composite structure and the diameter is around 13 nm. Further, it is shown through magnetisation and ESR study that the exchange interaction between magnetite and drug intercalated LDHs layers shifted the T-B of Fe3O4 in magnetic nanohybrid to lower temperatures. In vitro release study of nanohybrid particles at pH 7.4 in PBS and at 37 degrees C show a faster release for magnetic nanohybrids. The mechanism is probably due to combined effect of interparticle and heterogeneous diffusion via anionic exchange. (C) 2012 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2014-10-15T13:35:29Z
2014-10-15T13:35:29Z
2012
 
Type Article
 
Identifier MATERIALS RESEARCH BULLETIN, 47(3)571-579
http://dx.doi.org/10.1016/j.materresbull.2011.12.041
http://dspace.library.iitb.ac.in/jspui/handle/100/15018
 
Language en