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Synthesis of Imidazopyridines from the Morita-Baylis-Hillman Acetates of Nitroalkenes and Convenient Access to Alpidem and Zolpidem

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Title Synthesis of Imidazopyridines from the Morita-Baylis-Hillman Acetates of Nitroalkenes and Convenient Access to Alpidem and Zolpidem
 
Creator NAIR, DK
MOBIN, SM
NAMBOOTHIRI, INN
 
Subject ONE-POT SYNTHESIS
CONJUGATED NITROALKENES
EFFICIENT SYNTHESIS
CATALYZED SYNTHESIS
2-AMINOPYRIDINES
DERIVATIVES
3-COMPONENT
RECEPTORS
ESTERS
AMINOPYRIDINES
 
Description A variety of functionalized imidazo[1,2-a]pyridines have been synthesized through a one-pot, room temperature, and reagent-free reaction between MBH acetates of nitroalkenes and 2-aminopyridines. The reaction involves a cascade inter-intramolecular double aza-Michael addition of 2-aminopyridines to MBH acetates. Our methodology is marked by excellent yield, regioselectivity and, above all, adaptability to synthesize imidazopyridine-based drug molecules such as Alpidem and Zolpidem.
 
Publisher AMER CHEMICAL SOC
 
Date 2014-10-15T14:23:24Z
2014-10-15T14:23:24Z
2012
 
Type Article
 
Identifier ORGANIC LETTERS, 14(17)4580-4583
http://dx.doi.org/10.1021/ol3020418
http://dspace.library.iitb.ac.in/jspui/handle/100/15093
 
Language en