Record Details

Endogenous CO2 may inhibit bacterial growth and induce virulence gene expression in enteropathogenic Escherichia coli

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Endogenous CO2 may inhibit bacterial growth and induce virulence gene expression in enteropathogenic Escherichia coli
 
Creator MARTINEZ, H
BUHSE, T
RIVERA, M
PARMANANDA, P
AYALA, G
SANCHEZ, J
 
Subject Bacterial growth kinetics
Bacterial growth auto-inhibition
Carbon dioxide inhibited growth
Culture surface-to-volume ratio
Volatile bacterial growth inhibitor
Carbon dioxide-induced virulence
ENTEROCYTE EFFACEMENT
CARBON-DIOXIDE
CITROBACTER-RODENTIUM
STATIONARY-PHASE
CHOLERA-TOXIN
EL-TOR
LOCUS
SECRETION
PROTEINS
SEQUENCE
 
Description Analysis of the growth kinetics of enteropathogenic Escherichia coil (EPEC) revealed that growth was directly proportional to the ratio between the exposed surface area and the liquid culture volume (SA/V). It was hypothesized that this bacterial behavior was caused by the accumulation of an endogenous volatile growth inhibitor metabolite whose escape from the medium directly depended on the SA/V. The results of this work support the theory that an inhibitor is produced and indicate that it is CO2. We also report that concomitant to the accumulation of CO2, there is secretion of the virulence-related EspB and EspC proteins from EPEC. We therefore postulate that endogenous CO2 may have an effect on both bacterial growth and virulence. (C) 2012 Elsevier Ltd. All rights reserved.
 
Publisher ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
 
Date 2014-10-15T16:36:11Z
2014-10-15T16:36:11Z
2012
 
Type Article
 
Identifier MICROBIAL PATHOGENESIS, 53(1)49-55
http://dx.doi.org/10.1016/j.micpath.2012.04.002
http://dspace.library.iitb.ac.in/jspui/handle/100/15225
 
Language en